蘭州大學基礎醫學院導師介紹：譚繼英

導師信息來源：中國考研網 2015-07-28　相關院校：蘭州大學

姓名：譚繼英
Name Tan, Jiying
職務：教授（四級），碩士生導師
Duty Professor
專業：免疫學、循證醫學
Major Immunology & Evidence Based Medicine
E-mail: tanjy@lzu.edu.cn

一、科研方向

1. HIV感染免疫細胞相關分子機制和HIV潛伏感染；
2. 結核疫苗和結核免疫
3. 基于HIV和結核病相關的循證醫學與免疫學研究；
Research Interests：
1.   The Molecular mechanisms of HIV infect Immnuocytes & HIV latent infection
2.   The Vaccine of Tuberculosis & Immune of Tuberculosis
3.   Evidence Based Medicine & Immunology of HIV and Tuberculosis

二、個人簡歷

1. 2011年6月至2014年3月在美國食品藥品管理局（Food and Drug of Administration, FDA）生
物安全評價中心（Center for Biologics Evaluation and Research, CBER）分子病毒學研究室（Laboratory of Molecular Virology, LMV）博士后，主要從事HIV的分子免疫學機理的研究。
2. 2003年12月至2014年4月蘭州大學免疫學研究所副教授。
3. 2006年6月在四川大學華西臨床醫學院外科學專業移植免疫和循證醫學方向獲得博士學位。
Resume：
1.    Postdoc   May 2011 – March 2014
Lab. of Molecular virology (LMV), Center for Biologics Evaluation and Research,
(CBER), Food and Drug of Administration, (FDA).   My researches are to study on effects of host factors on HIV-1 replication and reactivation from its latent infection:
Key contribution:
Determined the mechanisms by which HIV-1 induces infected cell death;
Found the effects of molecules from apoptotic/autophagy pathways on HIV-1 replication;
--Some mechanisms of FLIP expression in HIV-1 replication,
--The effects of FADD knockdown on HIV-1 replication,
--Mechanisms of XIAP in HIV-1-induced cell death and HIV-1 replication,
Understand the effects of 2009 pandemic influenza H1N1 virus infection on HIV-1 infection,
replication and reactivation from HIV-1 latent infection.
2. Associated Professor Dec. 2003 - May 2011
Dept. of Immunology, School of Basic Medical Sciences, Lanzhou University
My researched fields were vaccine of Tuberculosis. The fund from Ministry of Health of CHINA to Study of pre-Clinic of Tuberculosis subunit vaccines.
3. Ph.D. Candidate    Sep. 2003 - Jun. 2006
Key Laboratory of Transplant Engineering and Immunology, and Ministry of Health, and Chinese Centre of Evidence–Based Medicine, West China Hospital, West china medical school, Sichuan University, Chengdu 610041, CHINA. My researches were experiment of immunotolerance and review of infection after renal transplantation.

三、主要科研信息

（一）參與合作的主要課題：
1.   參加FDA的項目：NHLBI 13， To test and compare HIV from Cameroon in diagnosis and pathology;
2.   參加FDA的項目： NHLBI 13，To test and diagnosis using new technology
3.   國家科技重大研究專項（2012ZX10003-008-006）， “結核病創新型疫苗的研制”子課題“結核病免疫加強用亞單位疫苗臨床前研究”，子課題下部分研究。
4.   中央高校基本科研業務費專項資金, 蘭州大學重點項目: 結核分枝桿菌主要流行菌株致病機制與疫苗研究。（lzujbky-2010-k07），主持子項。
5.   國家科技重大研究專項（2008ZX10003011），“結核分枝桿菌感染的免疫保護機制”子課題“結核免疫病理分子機制”，子課題下部分研究。
6.   甘肅省鄉鎮衛生院繼續教育群隨機實驗:CMB項目（CBM09-944）

（二）主要文章（Publication）
1.    Jiying Tan, Xue Wang*, Krishnakumar Devadas, Jiangqin Zhao, Panhe Zhang, Indira Hewlett*.   Some mechanisms of FLIP expression in inhibition of HIV-1 replication in Jurkat cells, CD4+ T cells and PBMCs. J Cell Physiol. 2013: 228 (12): 2305-13
2.    Xue Wang*, Jiying Tan, Jiangqin Zhao, Viswannath Ragupathy, Mohan Haleyurgirisetty , Indira Hewlett*. Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs. Mol Cell Biochem, 2014; 393 (1-2):181-90. (共同第一)
3.    Xue Wang *, Jiying Tan, Olga Zouev , Jiangqin Zhao, Zhiping Ye, Indira Hewlett*. Novel pandemic influenza A (H1N1) virus infection modulates apoptotic pathways that impact its replication in A549 cells. Microbes Infect. 2014;16 (3): 178-86. (共同第一)
4.    Xue Wang* , Yamei Gao, Jiying Tan, Krishnakumar Devadas, Viswanath Ragupathy, Kazuyo Takeda, Jiangqin Zhao, Indira Hewlett*. HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells. Cellular Signaling 2012; 24 1414–1419
5.    Tan JY, Li SH, Yang KH,. Ustekinumab，a human interleukin-12/23 monoclonal antibody，in patients with psoriasis: A meta-analysis. Journal of Dermatological treatment. 2011; 22: 323–336
6.    謝富佳，譚繼英（通訊作者）*，喬梅，梁正羽，王世婷，唐克峰，祝秉東，楊燕，章國平. CFP21-ELISPOT方法的建立及其在結核分枝桿菌感染診斷中的應用. 中國病原生物學雜志2011,6(9): 647-683
7.    謝富佳，譚繼英（通訊作者）*，梁正羽，喬梅，祝秉東，吳玉敏，楊燕，章國平. 結核分枝桿菌培養濾液蛋白21(CFP21)的基因克隆、表達及純化. 中國人獸共患病學報. 2011,27(2): 117-119
8.    吳玉敏, 譚繼英（通訊作者）*，王革，劉萬波，胡麗娜，祝秉東. 核分枝桿菌Mtb8. 4- spx 和Hspx-Mtb8. 4重組基因克隆及表達. 中國病原生物學雜志. 2010；6（5）：414-417
9.    李少紅，馬彬，譚繼英（通訊作者）*，楊克虎. 依那西普治療強直性脊柱炎的系統評價. 中國循證醫學雜志. 2009, 9(4): 423-429
10. 安睿曉，田金徽，譚繼英（通訊作者）*, 楊克虎. 環磷酰胺聯合靜脈注射免疫球蛋白治療系統性紅斑狼瘡的系統評價等. 中國循證醫學雜志，2011, 11(3): 320-324
11. JY. Tan, N. Zhao, Y.P. Li*. Steroid Withdrawal Increases Risk of Acute Rejection But Reduces Infection：A System Review in Renal Transplantation. Transplantation proceedings 2006 Sep;38(7):2054-6 (The 9th Congress of Asian Society of Transplantation. Oral）