蘭州大學生命科學學院導師介紹：何永興

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學習經歷

2011/02-2013/02，加州大學伯克利分校，生物物理系，博士后

2005/09-2010/12，中國科大，生化與分子生物系，博士

2001/09-2005/07，中國科大，生命科學院，學士。

工作經歷

2013/03-今，蘭州大學引進人才，副教授。

教學及指導研究生情況 主講本科生必修課《生物信息學》，選修課《生物大分子的結構與功能》。

發表論文及專著

1: Mu Y, Lian FM, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ, Chen X. The
N-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena
crocea is involved in its biological functions. PLoS One. 2013;8(2):e57061.

2: He YX, Zhang NN, Li WF, Jia N, Chen BY, Zhou K, Zhang J, Chen Y, Zhou CZ.
N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in
response to pH decrease. J Mol Biol. 2012 May 4;418(3-4):197-207.

3: Kang Y, He YX, Zhao MX, Li WF. Structures of native and Fe-substituted SOD2
from Saccharomyces cerevisiae. Acta Crystallogr Sect F Struct Biol Cryst Commun.
2011 Oct 1;67(Pt 10):1173-8.

4: Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ. Crystal
structure of the 30 K protein from the silkworm Bombyx mori reveals a new member
of the β-trefoil superfamily. J Struct Biol. 2011 Jul;175(1):97-103.

5: Du Y, Shi WW, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the
substrate-binding protein provide insights into the multiple compatible solute
binding specificities of the Bacillus subtilis ABC transporter OpuC. Biochem J.
2011 Jun 1;436(2):283-9.

6: Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou
CZ, Chen Y. Crystal structure of the mucin-binding domain of Spr1345 from
Streptococcus pneumoniae. J Struct Biol. 2011 Apr;174(1):252-7.
7: Ma G, Yu J, Xiao Y, Chan D, Gao B, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L,
Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L. Indian hedgehog
mutations causing brachydactyly type A1 impair Hedgehog signal transduction at
multiple levels. Cell Res. 2011 Sep;21(9):1343-57.8: Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen Y, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010 Dec 15;432(3):445-50.

9: Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC, Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12487-92.

10: Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010 Sep;78(12):2714-9.

11: Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ. Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6. J Mol Biol. 2010 May 14;398(4):614-22.

12: Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins. 2010 Jun;78(8):1999-2004.

13: He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010 Feb 12;285(7):4603-11.

14: Teng YB, Jiang YL, He YX, He WW, Lian FM, Chen Y, Zhou CZ. Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103. BMC Struct Biol. 2009 Oct 24;9:67.

15: Ma XX, Jiang YL, He YX, Bao R, Chen Y, Zhou CZ. Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family. EMBO Rep. 2009 Dec;10(12):1320-6.

16: Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ. Crystal structure of Arabidopsis translation initiation factor eIF-5A2. Proteins. 2009 Nov 15;77(3):736-40.

17: Wang Y, He YX, Yu J, Zhou CZ. Cloning, overproduction, purification, crystallization and preliminary X-ray diffraction analysis of yeast glutaredoxin Grx5. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):651-3.

18: He YX, Gui L, Liu YZ, Du Y, Zhou Y, Li P, Zhou CZ. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. Proteins. 2009 Jul;76(1):249-54.

19: Huang L, Sun F, Liang C, He YX, Bao R, Liu L, Zhou CZ. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009 May 1;75(2):524-7. doi: 10.1002/prot.22346.

20: Zhang WJ*, He YX*, Yang Z, Yu J, Chen Y, Zhou CZ. Crystal structure of glutathione-dependent phospholipid peroxidase Hyr1 from the yeast Saccharomyces cerevisiae. Proteins. 2008 Dec;73(4):1058-62.

21: Wang S, He YX, Bao R, Teng YB, Ye BP, Zhou CZ. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3(2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):847-50.

參與翻譯編寫《英漢生物技術詞典》，化學工業出版社，2009.