蘭州大學生命科學學院導師介紹：常民

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學習經(jīng)歷

1993年-1998年，同濟大學醫(yī)學院，學士；
2000年-2005年，蘭州大學生命科學學院，碩博連讀，博士，導師：王銳教授。
工作經(jīng)歷 2005年-2009年，蘭州大學生命科學學院，講師；
2009年-至今，蘭州大學生命科學學院，副教授。
教學及指導研究生情況 承擔本科生《生物化學》、《動物生理學》、《多肽科學》、《生物學文獻檢索》、《人體解剖生理學》、《動物生理學實驗》課程。

碩士生導師。

發(fā)表論文及專著

Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Han RW, Chang M*, Wang R*. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 doi:10.1016/j.nlm.2015.05.010 (SCI)
Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M*, Wang R*. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015;286:39-48. (SCI)
Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem. 2014 ;107:32-6. (SCI)
Han, RW, Zhang RS, Xu HJ, Chang M, Peng YL, Wang R*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Abeta42 in mice novel object and object location recognition tasks, Neuropharmacology, 2013;70:261-7.(SCI)
Han RW, Zhang RS, Chang M, Peng YL, Wang P, Hu SQ, Choi CL, Yin M, Wang R*, Han YF. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Res. 2012;1470:59-68. (SCI)
Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang R*. Effects of central neuropeptide S in the mouse formalin test. Peptides. 2010;31(10):1878-83. (SCI)
Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang R*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-63. (SCI)
Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R*. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009;1271:36-48. (SCI)
Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R*. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul. Pept. 2009;156:90-5. (SCI) (共同第一作者)
Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;30(7): 1313-17. (SCI) (共同第一作者)
Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro. Lett. 2009;455:74-7. (SCI)
Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R*. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept. Lett. 2009;16:1074-80. (SCI)
常民, 彭雅麗, 李威, 王銳. 神經(jīng)肽S的功能與構(gòu)效關(guān)系研究進展. 生物物理學報. 2009;03:175-82.
常民, 李威, 王銳. Mrg受體家族的研究進展. 中國藥理學通報. 2009;07:841-44.
Li Z, Zhou LX, Zhang BH, Yan X, Li J, Peng YL, Chang M, Dong SL, Wang R*. Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.Pharmazie. 2008;63(9):676-85.(SCI)
Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R*. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI)
Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R*. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4, Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul. Pept. 2006;134:75-81. (SCI) (共同第一作者)
Fang Q, Guo J, Peng YL, Chang M, He F, Chen Q, Wang R*. In vitro and in vivo studies of dansylated compounds, the putative agonists and antagonists on neuropeptide FF receptors. Peptides. 2006;27:1297-304. (SCI)
Yang Q, Chen Y, Fu C, Chang M, Peng YL, Wang R*. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.Protein Pept Lett. 2006;13(2):185-8.(SCI)
Fang Q, Guo J, He F, Peng YL, Chang M, Wang R. In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides. 2006;27:2207-13. (SCI)
Fang Q, Guo J, Chang M, Chen LX, Chen Q, Wang R*.Neuropeptide FF receptors exert contractile activity via inhibition of nitric oxide release in the mouse distal colon.Peptides. 2005;26(5):791-7.(SCI)
Chang M, Peng YL, Dong SL, Han RW, Li W, Yang DJ, Chen Q, Wang R*. Structure-activity studies on different modifications of nociceptin/orphanin FQ: identification of highly potent agonists and antagonists of its receptor. Regul. Pept. 2005;130:116-22. (SCI)

專利：

一種固液相縮合制備胸腺肽α1的方法，申請?zhí)枺篊N201310523706.1；
液相片段縮合制備胸腺肽α1的方法，申請?zhí)枺篊N201310523577.6；
片段縮合制備醋酸鮭魚降鈣素的方法，申請?zhí)? CN201410420967.5;
片段縮合制備特利加壓素的方法，申請?zhí)? CN201410554759.4
一種片段縮合制備曲普瑞林的方法，申請?zhí)? CN201410743707.1
 一種片段縮合制備醋酸去氨加壓素的方法，申請?zhí)? CN201410748612.9
一種片段縮合制備醋酸阿托西班的方法，申請?zhí)? CN201410802681.3
片段縮合制備利拉魯肽的方法，申請?zhí)枺篊N201510079168.0

研究方向

1、神經(jīng)肽的高級神經(jīng)功能作用

2、多肽藥物

3、G蛋白受體藥理學

主持項目：

1、神經(jīng)肽S的構(gòu)效關(guān)系及其胃腸道生理活性研究（30600094）。國家自然科學基金委。

2、新的神經(jīng)肽系統(tǒng)在焦慮與抑郁疾病中作用機理的研究。甘肅省科技廳。

榮譽、獲獎

1、常民，首屆蘭州大學隆基青年教師教學新秀獎。

2、陳強，董守良，常民，甘肅省精品課程《動物生理學》。

3、陳強，董守良，常民，教育部雙語教學示范課程《動物生理學》。

4、Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R. Gayle and Richard Olson Prize for Most Outstanding Behavioral Paper Published the Previous Year in the Journal Peptides, 2010.

5、王銳，方泉、于燁、張邦治、常民、劉紅美，《多肽新藥研發(fā)的化學修飾的專利技術(shù)》，甘肅省技術(shù)發(fā)明一等獎。