蘭州大學(xué)生命科學(xué)學(xué)院導(dǎo)師介紹：吉尚戎

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學(xué)習(xí)經(jīng)歷

■ 1994.9-1998.7，北京大學(xué)醫(yī)學(xué)部，獲理學(xué)學(xué)士學(xué)位；
■ 1998.9-2003.7，清華大學(xué)生物科學(xué)與技術(shù)系，獲理學(xué)博士學(xué)位。

工作經(jīng)歷

■ 2003.9至今，蘭州大學(xué)生命科學(xué)學(xué)院，教學(xué)科研。
教學(xué)及指導(dǎo)研究生情況 研究團(tuán)隊：教授2人、副教授1人、講師1人、實驗師1人，研究生19人。

發(fā)表論文及專著

1. Zhang L., Liu S.-H., Wright T.T., Shen Z.-Y., Li H.-Y., Zhu W., Potempa L.A., Ji S.-R.*, Szalai A.J.*, Wu Y.* (2015) C-reactive protein directly suppresses T helper 1 cell differentiation and alleviates experimental autoimmune encephalomyelitis. Journal of Immunology, in press. (5-Year IF 5.57)

2. Su H.-X., Zhou H.-H., Wang M.-Y., Cheng J., Zhang S.-C., Hui F., Chen X-Z, Liu S.-H., Liu Q.-J., Zhu Z.-J., Hu Q.-R., Wu Y.*, Ji S.-R.* (2014) Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. Plos One, 9 (7): e102418. (5-Year IF 4.015)

3. Li H.-Y., Wang J., Wu Y.-X., Zhang L., Liu Z.-P., Filep J.G., Potempa L.A., Wu Y.*, Ji S.-R.* (2014) Topological localization of monomeric C-reactive protein determines pro-inflammatory endothelial cell responses. Journal of Biological Chemistry, 289 (20): 14283-14290. (5-Year IF 4.863)

4. Wang M.-Y., Zhou H.-H., Zhang S.-C., Hui F., Zhu W., Su H.-X., Guo H.-Y., Li X.-W., Ji S.-R.*, Wu Y.* (2014) Recurrent mutations at C-reactive protein promoter SNP position -286 in human cancers. Cell Research, 24(4): 505-508. (5-Year IF 11.078)

5. Zhang Y.-J., Shi J.-M., Bai C.-J., Wang H., Li H.-Y., Wu Y.*, Ji S.-R.* (2012) Intra-membrane oligomerization and extra-membrane oligomerization of amyloid-β peptide are competing processes as a result of distinct patterns of motif interplay. Journal of Biological Chemistry, 287(1): 748-756. (5-Year IF 4.863)

6. Wang M.-Y., Ji S.-R., Bai C.-J., El Kebir D., Li H.-Y., Shi J.-M., Zhu W., Costantino S., Zhou H.-H., Potempa L.A., Zhao J., Filep J.G.*, Wu Y.* (2011) A redox switch in C-reactive protein modulates activation of endothelial cells. FASEB Journal, 25(9): 3186-3196. (5-Year IF 6.045)

7.Liu R.-Q., Zhou Q.-H., Ji S.-R., Zhou Q., Feng D., Wu Y., Sui S.-F.* (2010) Membrane localization of β-Amyloid 1–42 in lysosomes: a possible mechanism for lysosome labilization. Journal of Biological Chemistry, 285(26): 19986-19996. (5-Year IF 4.863)

8.Ji S.-R., Ma L., Bai C.-J., Shi J.-M., Li H.-Y., Filep J.G., Potempa L.A., Zhao J., Wu Y.* (2009) Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft micro-domains. FASEB Journal, 23(6): 1806-1816. (5-Year IF 6.045)

9.Ji S.-R., Wu Y.*, Zhu L., Potempa L.A., Sheng F.-L., Lu W., Zhao J. (2007) Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRPm. FASEB Journal, 21(1): 284-294. (5-Year IF 6.045)

10.Ji S.-R., Wu Y.*, Potempa L.A., Liang Y.-H., Zhao J. (2006) Effect of modified C-reactive protein on complement activation: A possible complement regulatory role of mCRP in atherosclerotic lesions. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(4): 935-941. (5-Year IF 6.430)

11.Ji S.-R., Wu Y.*, Potempa L.A., Qiu Q., Zhao J. (2006) Interactions of C-reactive protein with low density lipoproteins: implications of an active role of modified C-reactive protein in atherosclerosis. International Journal of Biochemistry & Cell Biology, 384(4): 648-661. (5-Year IF 4.595)

12.Wu Y., He Y., Bai J., Ji S.-R., Tucker W.C., Chapman E.R.*, Sui S.-F.* (2003) Visualization of synaptotagmin I oligomers assembled on lipid monolayers. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2082-2087. (5-Year IF 10.727)

13.Ji S.-R., Wu Y., Sui S.-F.* (2002) Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (ABeta 1-40), which may potentially inhibit the fibril formation. Journal of Biological Chemistry, 277(8): 6273-6279. (5-Year IF 4.863)

14.Wu Y., Wang H.-W., Ji S.-R., Sui S.-F.* (2003) Two-dimensional crystallization of rabbit C-reactive protein monomeric subunits. Acta Crystallographica Section D-Biological Crystallography, 59(5): 922-926. (5-Year IF 9.416)

研究方向

■ 重要蛋白質(zhì)參與慢性炎癥疾病調(diào)控的分子機制；
■ 蛋白質(zhì)的結(jié)構(gòu)/功能、膜脂-蛋白相互作用；
■ 微小RNA（microRNA）與植物逆境適應(yīng)。

項目成果

■ 國家自然科學(xué)基金重點項目1項，面上項目8項（已結(jié)題5項）；
■ 國家自然科學(xué)基金優(yōu)秀青年基金1項；
■ 國家自然科學(xué)基金國際合作項目2項（已結(jié)題2項）；
■ 教育部新世紀(jì)優(yōu)秀人才支持計劃2項（已結(jié)題2項）；
■ 教育部博士點基金3項（已結(jié)題2項）；
■ 教育部科技研究重點項目1項（已結(jié)題1項）；
■ FEI合作研究基金1項；
■ 蘭州大學(xué)人才引進(jìn)專項2項（已結(jié)題2項）。

榮譽、獲獎

■ 清華大學(xué)優(yōu)秀博士學(xué)位論文二等獎，2003；
■ 國家自然科學(xué)二等獎（5/5），2005；
■ 教育部新世紀(jì)優(yōu)秀人才支持計劃，2007。