寧夏大學生命科學學院導師：王玉炯

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教授：王玉炯

王玉炯，寧夏大學教授、博士生導師，上海交通大學兼職教授、博士生導師。寧夏大學黨委常委、生命科學學院院長、西部特色生物資源保護與利用教育部重點實驗室主任。國家級教學名師、國務院政府特殊津貼獲得者、“基礎生物學”國家級教學團隊帶頭人、教育部“創新團隊發展計劃”培育團隊帶頭人、中央直接聯系的高級專家。
先后榮獲全國模范教師、全國師德先進個人、國家“百千萬人才工程”學術與技術帶頭人、教育部“跨世紀優秀人才”、“寶鋼優秀教師特等獎”、自治區“塞上英才”、自治區“有突出貢獻專業技術創新人才獎”、“100位為寧夏建設作出突出貢獻英雄模范人物”、寧夏“十大杰出青年”、自治區先進工作者等獎勵或榮譽稱號。兼任教育部生物技術、生物工程類專業教學指導委員會委員，寧夏回族自治區人民政府學位委員會委員，寧夏高等學校本科理工科類學科專業教學指導委員會主任委員，中國微生物學會理事，寧夏生物學會理事長、寧夏大學學術委員會副主任委員。《Vaccine》、《MolecularandCellularBiochemistry》、《BritishJournalofPharmaceuticalResearch》、《Molecules》等雜志長期審稿人，《高校生物學教學研究（電子版）》副主編、《寧夏大學學報》（自然版）常務編委，《JournalofBiochemistryandMolecularBiologyResearch》、《生命世界》、《生物學雜志》編委。
長期從事微生物學、分子生物學等學科的教學與科研工作。先后主持完成國家“863”計劃項目、國家“973”計劃項目（含前期研究專項）、國家自然科學基金項目、國家科技攻關和科技支撐計劃項目等國家級項目17項，教育部重點（重大）項目4項，自治區科技攻關計劃項目8項。獲國家一類新藥證書1項，獲省部級科技進步一等獎2項、二等獎5項，申請國家發明專利4項，獲國家級教學成果獎二等獎1項、自治區教學成果獎特等獎1項（以上獎項均為第一完成人）。在《Vaccine》、《PlosOne》、《MolecularImmunology》、《Mol.andCell.Bio.》等國內外期刊發表論文100余篇。曾多次應邀赴美國、日本、比利時等國家進行學術交流。
近期發表的主要論文:
1.ChunyanMa.,YongLi.,JinZeng,XiaolingWu,XiaomingLiu*andYujiongWang*.MycobacteriumbovisBCGTriggeredMyD88InducesmiR-124FeedbackNegativelyRegulatesImmuneResponseinAlveolarEpithelialCells,PLOSONE,April2014,Volume9,Issue4
2.ChunyanMa,YongLi,MinLi,GuangcunDeng,XiaolingWu,WilliamC.S.Cho,XiaomingLiu∗andYujiongWang∗.MicroRNA-124negativelyregulatesTLRsignalinginalveolarmacrophagesinresponsetomycobacterialinfection,MolecularImmunology,62(2014)150–158
3.WuLi,GuangcunDeng,MinLi,LipingZhao,XiaomingLiuandYujiongWang∗.ArecombinantadenovirusexpressingCFP10,ESAT6,Ag85AandAg85BofMycobacteriumtuberculosiselicitsstrongantigen-specificimmuneresponsesinmice,MolecularImmunology,62(2014)86–95
4.XiaolingWu,GuangcunDeng,JinZeng,ChunyanMa,XiaomingLiu*andYujiongWang*.ACaspase-DependentPathwayIsInvolvedinWnt/β-CateninSignalingPromotedApoptosisinBacillusCalmette-GuerinInfectedRAW264.7Macrophages,Int.J.Mol.Sci.2014,15,5045-5062
5.Peng-xinXu,Shao-weiWang,Xiao-linYu,Ya-jingSu,Yu-jiongWang∗,Rui-tianLiu∗.RutinimprovesspatialmemoryinAlzheimer’sdiseasetransgenicmicebyreducingA_oligomerlevelandattenuatingoxidativestressandneuroinflammation,BehaviouralBrainResearch,264(2014)173–180
6.BoYang,XiaomingLiu,MinLi,YiYangandYujiongWang∗.GeneticAssociationofrs1800780(A→G)PolymorphismoftheeNOSGenewithSusceptibilitytoEssentialHypertensioninaChineseHanPopulation,BiochemGenet(2014)52:71–78DOI10.1007/s10528-013-9628-3
7.J.X.Dai,X.M.LiuandY.J.Wang∗,DiversityofendophyticbacteriainCaraganamicrophyllagrowninthedesertgrasslandoftheNingxiaHuiAutonomousRegionofChina,GeneticsandMolecularResearch13(2):2349-2358(2014)
8.Y.Yang,J.R.Xu,X.M.Liu,J.Zhou,M.LiandY.J.Wang∗,Polymorphismsof+2836G>AintheapoEgenearestronglyassociatedwiththesusceptibilitytoessentialhypertensionintheChineseHuipopulation,GeneticsandMolecularResearch13(1):1212-1219(2014)
9.YujiongWang,YongLi,XiaomingLiu,*andWilliamCSCho,*GeneticandEpigeneticStudiesforDeterminingMolecularTargetsofNaturalProductAnticancerAgents,CurrentCancerDrugTargets,2013,13,506-518
10.YujiongWang,GuangcunDeng,XiaomingLiu*andWilliamC.Cho*.MonoclonalAntibodiesinLungCancer,ExpertOpinioninBiologicalTherapy,(2013)13(2):209-226
11.GuangcunDeng,JinZeng,MinjieJian,WenmiaoLiu,ZhongZhang,XiaomingLiuandYujiongWang*.NanoparticulatedHeat-stable(STa)andHeat-labileBsubunit(LTB)recombinanttoxinimprovesvaccineprotectionagainstEnterotoxigenicEscherichiacolichallengeinmouse,JournalBioscienceandBioengineering,JBiosciBioeng,2013.115(2):147-153
12.B.Yang,J.R.Xu,X.M.Liu,Y.Yang,M.LiandY.J.Wang∗.Polymorphismsofrs1799983(G>T)andrs1800780(A>G)oftheeNOSgeneassociatedwithsusceptibilitytoessentialhypertensionintheChineseHuiethnicpopulation,GeneticsandMolecularResearch12(3):3821-3829(2013)
13.MiaoGao,HuiYang,JiZhao,JunLiu,Yu-jiongWang*,Jian-guangSun*.Paenibacillusbrassicaesp.nov.,isolatedfromcabbagerhizosphereinBeijing,China,AntonievanLeeuwenhoekDOI10.1007/s10482-012-9849-1
14.XuezhangZhou,YuyanZhang,YongLi,XiujingHao,XiaomingLiu*,andYujiongWang*,AzithromycinSynergisticallyEnhancesAnti-ProliferativeActivityofVincristineinCervicalandGastricCancerCells.Cancers.2012.4,1318-1332
15.WuLi,GuangcunDeng,XiaomingLiuandYujiongWang*.RolesofMucosalimmunityinMycobacteriainfection,TuberculosisResearchandTreatment,2012.1-12.ArticleID791392
16.JinxiaDai,XiaomingLiuandYujiongWang*.GeneticdiversityandPhylogenyofRhizobiaisolatedfromCaraganamicrophyliagrownindesertsoilofNingxiainChina,GeneticandMolecularResearch,2012.11(3):2683-2693.
17.Shao-weiWang,Yu-JiongWang*,Ya-jingSua,Wei-weiZhou,Shi-gaoYang,RanZhang,MinZhao,Ya-NanLi,Zi-pingZhang,Da-weiZhan,Rui-tianLiu.Rutininhibitsb-amyloidaggregationandcytotoxicity,attenuatesoxidativestress,anddecreasestheproductionofnitricoxideandproinflammatorycytokines.NeuroToxicology,2012.33(3):p.482-90.
18.Xue,D.,M.Zhao,Y.J.Wang*,Rui-tianLiu.etal.AmultifunctionalpeptiderescuesmemorydeficitsinAlzheimer'sdiseasetransgenicmicebyinhibitingAbeta42-inducedcytotoxicityandincreasingmicroglialphagocytosis.NeurobiolDis,2012.46:701-9
19.XuezhangZhou,FangJiaandYujiongWang*.TotalAlkaloidsofSophoreaalopecuroides-induceddown-regulationofAcrAB-ToLCeffluxpumpreversessusceptibilitytoCiprofloxacininclinicalmultidrugresistantEscherichiacoliisolates.PhytotherapyResearch,2012.doi:10.1002/ptr.4623.
20.YongLi,YujiongWang*andXiaomingLiu*,TheroleofairwayepithelialcellsinresponsetoMycobacteriainfection,ClinicalandDevelopmentalImmunology,2012.12:DOI:10.1155/2012/791392
21.JinruiXu,YiYang,XiaomingLiu,JingyinSunandYujiongWang*.Geneticvariationandsignificantassociationofpolymorphismrs7700944G>AofTIM-4genewithRheumatoidArthritisintheChineseHanandHuiPopulations.InternationalJournalofImmunogenetics,2012.39(5):409-413.
22.XuezhangZhou,FangJia,XiaomingLiu,CongYangandYujiongWang*.TotalAlkaloidsfromKudouziincreasesusceptibilityofExtended-Spectrumb–Lactamases-producingEscherichiacoliisolatestoCefotaximeandCeftazidime.ChineseJournalofIntegrativeMedicine,2012,18(2):DOI:10.1007/S11655-01100899-4
23.JinruiXu,YiYang,XiaomingLiu,JingyinSunandYujiongWang*.AssociationofthePolymorphismsofTIM-1GenewithRheumatoidArthritisintheChineseHuiMinorityEthnicPopulation.GeneticandMolecularResearch,2012,11(1):61-69.
24.XuezhangZhou,LiZhao,XiaomingLiu,XueqiangLi,FangJiaYujiongWang*.Antimycobacterialandsynergisticeffectsof18-β-glycyrrhetinicacidorglycyrrhetinicacid-30-piperazineincombinationwithisoniazid,rifampicinorstreptomycinagainstMycobacteriumbovis.PhytotherapyResearch,2012,26(2):253-258.
25.JinruiXu,YiYang,XiaomingLiu,andYujiongWang*.The-1541C>Tand+4259G>TofTIM-3PolymorphismsareassociatedwithRheumatoidArthritisintheChineseHuiPopulation.InternationalJournalofImmunogenetics,2011,38(6):513-518.
26.Xue-tingDu,LiWang,Yu-jiongWang*,MariaAndreasen,Da-weiZhan,YingFeng,MinLi,MinZhao,DanielOtzen,DiXue,YangYangandRui-tianLiu,A_1-16CanAggregateandInducetheProductionofReactiveOxygenSpecies,NitricOxide,andInflammatoryCytokines，JournalofAlzheimer’sDisease，2011.27(2):p.401-13.
27.XuezhangZhou,FangJia,XiaomingLiu,JinhuiYangandYujiongWang*.InVitrosynergisticinteractionof5-O-methylglovanonandampicillinagainstampicillinresistantStaphylococcusaureusandStaphylococcusepidermidisisolates.ArchivesofPharmacalResearch,2011,34(10):1751-1757.
28.YongLi,JingWang,HaiyanHe,LingjieMa,JinZeng,XiaomingLiu,JohnF.EngelhardtandYujiongWang*.ImmunohistochemicaldemonstrationofairwayepithelialcellmarkersofGuineaPig.TissueandCell,2011,43(5):283-290.DOI:10.1016/j.tice.2011.05.003
29.JinZeng,GuangcunDeng,JingWang,JingZhou,XiaomingLiu,QingXieandYujiongWang*.PotentialprotectiveimmunogenicityofrecombinantClostridiumperfringensa-β2-β1fusiontoxininmice,sowsandcows.Vaccine,2011,29(33):5459-5466.DOI:10.1016/j.
30.ZipingZhang,XiaomingLiu,XuZhang,JunhongLiu,YanfangHao,XueyunYang,andYujiongWang*.ComparativeevaluationoftheantioxidanteffectsofthenaturalvitaminCanalog2-O-β-D-glucopyranosyl-L-ascorbicacidisolatedfromGojiberryfruit.ArchivesofPharmacalResearch,2011,34(5):801-810,DOI:10.1007/s12272-011-0514-4.
31.MinLi,ChunjiMa,XiaomingLiu,DongZhao,QingchunXuandYujiongWang*.MolecularcloningofHSP70inMycoplasmaovipeneumoniaeandcomparisonwiththatofothermycoplasmas.GeneticandMolecularResearch,2011,10(2):834-848,DOI10.4238/vol10-2gmr1193.
32.XuezhangZhou，ZhenweiSong，XiaomingLi，FangJia，YujiongWang*.ProductionofRecombinantPorcineInterferonalphaUsingPHB–Intein-MediatedProteinPurificationStrategy.ApplBiochemBiotechnol.(2011)163:981–993.
33.ZipingZhang,XiaomingLiu,TaoWu,JunhongLiu,XuZhang,XueyunYang,MichaelJ.Goodheart,JohnF.Engelhardt,YujiongWang*.SelectivesuppressionofcervicalcancerHelacellsby2-O-β-D-glucopyranosyl-L-ascorbicacidisolatedfromthefruitofLyciumbarbarumL.CellBiolToxicol.(2011)27:107-121
34.GuangxianXu,HaoJia,YongLi,XiaomingLiu,MinLi,YujiongWang*.HemolyticphospholipaseRv0183ofMycobacteriumtuberculosisinducesinflammatoryresponseandapoptosisinalveolarmacrophageRAW264.7cells.Can.J.Microbiol.2010,56:916–924.
35.GuangxianXu,YanZhang,HaoJia,JuanLi,XiaomingLiu,JohnF.Engelhardt,YujiongWang*.CloningandidentificationofmicroRNAsinbovinealveolarmacrophages.MolCellBiochem.2009,332:9-16.
36.WangXP,ZhangJH,WangYJ*,FengY,ZhangX,SunXX,LiJL,DuXT,LambertMP,YangSG,ZhaoM,KleinWL,LiuRT.Conformation-dependentsingle-chainvariablefragmentantibodiesspecificallyrecognizebeta-amyloidoligomers,FEBSLetters,2009,583:579-584.
37.YingFeng,Xiao-pingWanga,Yu-jiongWang*,Xue-tingDua,Xiao-xiaSun,MinZhao,LeiHuang,Rui-tianLiu,Resveratrolinhibitsbeta-amyloidoligomericcytotoxicitybutdoesnotpreventoligomerformation.NeuroToxicology.2009,30:986-995.
注：“*”為通訊作者或并列第一作者