華東理工大學生物工程學院生物工程研究生導師：謝靜莉

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華東理工大學生物工程學院生物工程研究生導師謝靜莉介紹如下：

食品科學專業：碩士生導師

生物工程專業：碩士生導師

生物工程領域：工程碩士導師

謝靜莉，女，工學博士，副研究員，華東理工大學生物工程學院。

現任生物反應器工程國家重點實驗室常務副主任，曾任華東理工大學生物工程學院食品科學與工程系副主任、常務副主任。先后作為課題組長或負責人承擔科技部863計劃、國家自然科學基金青年基金項目、上海市科技攻關項目子課題，科技部973計劃項目子課題等多項國家及省部級課題，并與雀巢上海研發有限公司、美國派拉蒙農場有限公司、上海漢康豆類食品有限公司等多家國內外企業進行合作。發表學術論文53篇，其中以通訊/第一作者身份發表SCI論文30篇，授權專利7項。

主要經歷：

2005年4月至今：華東理工大學生物工程學院食品科學與工程系教師，生物反應器工程國家重點實驗室固定人員

2003年10月-2005年3月于西班牙：CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS（最高科學理事會）CENTRO DE INVESTIGACIONES BIOLOGICAS （生物研究中心），分子生物學博士后研究工作

2003年6月畢業于華東理工大學生物工程學院生物反應器工程國家重點實驗室，工學博士

2000年7月畢業于華東理工大學生物工程學院生物反應器工程國家重點實驗室，工學碩士

1996年7月畢業于華東理工大學能源化工系，工學學士

主要研究方向：

食品生物技術：基于功能基因組學的乳酸菌益生功能研究與天然活性物質代謝途徑研究；基于結構生物學的食品酶學研究與酶制劑開發；具有益生和促進健康作用的發酵食品開發技術。

功能性食品：基于生物信息學與生物計算學的食源性活性肽靶向酶解與構效關系研究；活性肽類功能食品開發技術。

主講課程：

食品科學碩士點專業主干課程：食品生物技術與工程

食品科學與工程系本科課程：專業英語、分子營養學

論文及專利（2014-2017）：

論文
1.Guo M#, Chen X#, Wu J, Zhang L, Huang W, Yuan Y, Fang M, Xie J*, Wei D. Angiotensin I-converting enzyme inhibitory peptides from Sipuncula (Phascolosoma esculenta). Process Biochemistry. 2017, DOI 10.1016/j.procbio.2017.08.009

2.Zhu Q, Chen X, Wu J,Zhou Y, Qian Y, Fang M, Xie J*, Wei D. Dipeptidyl peptidase IV Inhibitory peptides from Chlorella vulgaris: In silico gastrointestinal hydrolysis and molecular mechanism. European Food Research and Technology. 2017, DOI 10.1007/s00217-017-2879-1

3.Zhang J, Zhao L, Gao B, Wei W, Wang H, Xie J*. Protopectinase production by Paenibacillus polymyxa Z6 and its application in pectin extraction from apple pomace. Journal of Food Processing and Preservation. 2017(1): e13367

4.Yang Y, Sun J, Wu J, Zhang L, Du L, Matsukawa S, Xie J*, Wei D. Characterization of a novel α-L-arabinofuranosidase from Ruminococcus albus 7 and rational design for its thermostability. Journal of Agricultural and Food Chemistry. 2016 Dec, 64 (40): 7546–7554

5.Lang C, Yang R, Yang Y, Zhao L, Gao B, Wei W, Wang H, Matsukawa S, Xie J*, Wei D. An acid-adapted endo-a-1,5-L-arabinanase for pectin releasing. Applied Biochemistry and Biotechnology. 2016 Nov, 180 (5): 900-916

6.Zhu Q#, Qian Y#, Yang Y, Wu W, Xie J*, Wei D. Effects of carbonyl iron powder on iron deficiency anemia and its subchronic toxicity. Journal of Food and Drug Analysis. 2016 Oct, 24 (4): 746-753

7.Du L, Brenner T, Xie J, Matsukawa S*. A study on phase separation behavior in kappa/iota carrageenan mixtures by micro DSC, rheological measurements and simulating water and cations migration between phases. Food Hydrocolloids. 2016, 55:81-88 

8.Zhao L, Lin J, Wang H, Xie J, Wei DZ*. Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans. Bioprocess and Biosystems Engineering. 2015, 38 (12):2487-2495

9.Wang Y, Wang Y, Lang C, Wei D, Xu P, Xie J*. Genome Sequence of Lactobacillus curieae CCTCC M 2011381T, a Novel Producer of Gamma-aminobutyric Acid. Genome Announcements. 2015, 3(3):e00552-15

10.Yang Y, Zhang L, Guo M, Sun J, Matsukawa S, Xie J*, Wei D. Novel α-L-arabinofuranosidase from Cellulomonas fimi ATCC 484 and its substrate-specificity analysis with the aid of computer. Journal of Agricultural and Food chemistry. 2015, 63(14):3725-3733

11.Chen M, Lei X, Chen C, Zhang S, Xie J*, Wei D. Cloning, overexpression and characterization of a highly active endoinulinase gene from Aspergillus fumigatus CL1 for production of inulo-oligosaccharides. Applied Biochemistry and Biotechnology. 2015, 175(2):1153-1167

12.Fan J, Cui Y, Zhou Y, Wan M, Wang W, Xie J, Li Y*. The effect of nutrition pattern alteration on Chlorella pyrenoidosa growth, lipid biosynthesis-related gene transcription. Bioresource Technology. 2014, 164(1):214-220.

13.Liu Y, Zhang L, Guo M, Wu H, Xie J*, Wei D. Virtual screening for angiotensin I-converting enzyme inhibitory peptide from Phascolosoma esculenta. Bioresources and Bioprocessing. 2014, 1:17

14.Wang S, Yang Y, Zhang J, Sun J, Matsukawa S, Xie J*, Wei D. Characterization of abnZ2 (yxiA1) and abnZ3 (yxiA3) in Paenibacillus polymyxa, encoding two novel endo-1,5-α-L-arabinanases, AbnZ2 (YxiA1) and AbnZ3 (YxiA3). Bioresources and Bioprocessing. 2014, 1: 14

15.Wang S, Yang Y, Yang R, Zhang J, Chen M, Matsukawa S, Xie J*, Wei D. Cloning and characterization of a cold-adapted endo-1,5-α-L-arabinanase from Paenibacillus polymyxa and rational design for acidic applicability. Journal of Agricultural and Food chemistry. 2014, 62(33): 8460-8469

16.Wu H, Liu Y, Guo M, Xie J*, Jiang X*. A Virtual screening method for inhibitory peptides of angiotensin I converting enzyme. Journal of Food Science. 2014, 79(9): 1635-1642

17.WuY, LiuY, GuoM, LiP, DuL, FangM, WuH,XieJ*, WeiD. Nutritional composition and antihypertensive activity on spontaneously hypertensive rats of sipuncula Phascolosoma esculenta. Food and Function. 2014, 5 (9): 2317-2323

18.Li P, Jia J, Fang M, Zhang L, Guo M, Xie J*, Xia Y, Zhou L, Wei D. In vitro and in vivo ACE inhibitory of pistachio hydrolysates and in silico mechanism of identified peptide binding with ACE.Process Biochemistry. 2014, 49(5): 898-904

19.Li P, Jia J, Zhang D, Xie J*, Xu X, Wei D. In vitro and in vivo antioxidant activities of flavonoidfrom celery (Apium graveolens L. var. dulce). Food and Function. 2014, 5:50-56

20.Chen J, Yang R, Chen M, Wang S, Li P, Xia Y, Zhou L, Xie J*, Wei D. Production optimization and expression of pectin releasing enzyme from Aspergillus oryzae PO. Carbohydrate Polymers. 2014, 101:89-95

21.Zhou P, Zhang Y, Wang P, Xie J*, Ye Q.Butanol production from glycerol by recombinant Escherichia coli. Annuals of Microbiology. 2014, 64:219-227

授權專利

1、謝靜莉，張龍，曹小飛，高允盛，趙丹，許學書. 一種含豆乳的奶酪及其制備方法. ZL 200810202514.X

2、張 晞，許學書，謝靜莉，余東輝，夏月蘭. 封閉式固體發酵反應裝置. ZL 200910047129.7

3、謝靜莉，張龍，許學書，高允盛，曹小飛，林炯.一種拉絲型混合干酪的制作方法及獲得的混合干酪. ZL 200910051486.0

4、謝靜莉，李晴輝，魏東芝. 一種涂抹型大豆干酪及其制作方法. ZL 201110358380.2

5、謝靜莉，雷曉，孫貴朋，魏東芝. 一種食源性乳酸菌及其應用. ZL 201210044449.9

6、謝靜莉，方明，李鵬，杜磊，吳燕玲，魏東芝. 降血壓多肽. ZL 2013101240332

7、謝靜莉，方明，張旭晟，鄧高靜，吳燕玲，王波，束雯婷，李瑩，杜磊，李鵬. 蓮子用于制備ACE抑制劑的應用. ZL 201210137731.1

聯系方式：

電話：64251803 (O), 64252563 (Lab)

E-mail: jlxie@ecust.edu.cn