清華大學環境學院研究生導師：周小紅

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姓　　名：周小紅

所在單位：水環境保護教研所

職　　稱：副教授

郵寄地址：清華大學中意節能樓424室

電子郵件：xhzhou@mail.tsinghua.edu.cn

教育背景

1998.9-2002.7 同濟大學 環境工程 學士

2002.9-2007.7 清華大學 環境工程 博士

工作履歷

2013.12-至今 清華大學 環境學院 副教授

2014.2-2014.11 英國南安普頓大學光電中心 訪問學者

2009.07-2013.12 清華大學 環境學院 講師

2008.09-2009.03 加拿大阿爾伯塔大學 訪問學者

2007.07-2009.06 清華大學 博士后

教學：

主講研究生課程：Biofilms: fundamentals to applications(2015-今，32學時)

本科生課程：水中污染物快速檢測生物傳感器(2017-今，16學時)

本科生課程：環境毒理與健康(2017-今，負責16學時)

研究生課程：現代環境微生物監測原理與技術(2014-今，負責6學時)

學術兼職

Nature期刊Scientific Reports期刊編委(2015-至今)

生物傳感、生物芯片與納米生物技術專業委員會(籌) 委員

國際水協會 會員

中國環境科學學會 高級會員

International Conference on Sensor Device Technologies and Applications (SENSORDEVICES) 國際會議技術方案委員會委員

研究領域

環境監測、環境污染物生物化學分析技術、生物傳感器及納米生物傳感器

?研究概況

1. 國家自然科學基金中英交流項目，21711530214，用于環境生物檢測的多通道集成光波導芯片，2017/04-2019/03，在研，主持

2. 國家自然科學基金面上基金項目，21677082，基于工程化適配體的水中抗生素快速定量倏逝波傳感檢測技術，2017/01-2020/12，在研，主持

3. 國家科技部重大儀器開發專項，2012YQ03011101-01，多指標平面波導生物芯片的開發，2012/09-2017/09，在研，參與

4. 國家科技部863計劃，2014AA06A506，水質安全生物預警監測技術與系統，2014/01-2017/12，在研，參加

5. 北京市自然科學基金項目，8132032，基于微電極測試的污水深度處理反硝化生物濾池脫氮模型，2013/01-2015/12，已結題，主持

6. 清華大學國際科技合作項目，20133000129，基于功能核酸的重金屬檢測技術研究，2013/01-2014/12，已結題，主持

7. 國家自然科學基金青年基金，51108243，人工金屬氧化物納米顆粒在污水生物處理系統中的歸趨及對微生物聚集體活性的影響，2012/01-2014/12，結題，負責人

8. 微生物聚集體微觀測試平臺，環境模擬與污染控制國家重點實驗室科研儀器設備基金，2012/01-2014/12，結題，主要參加人

9. 國家重大水專項，2011ZX07313-002，污水處理系統區域優化運行及城市面源削減技術研究與示范，2011/07-2015/12，結題，參加人

10. 浙江省自然科學基金一般項目，Y5080009，多元因素影響的水體磷酸鹽微傳感器信號解析及其芯片設計的研究，2009/01-2010/12，結題，負責人

11. 國家科技部863計劃，2009AA06A417，重大環境污染事件特征污染物檢測系統與技術集成，2009/08-2012/09，結題，參加

12. 10. 國家重大水專項，2009ZX07313，城市污水處理廠與排水管網優化技術研究與示范，2009/01-2011/12，結題，參加

13. 國家自然科學基金面上項目，50478009，生物載體內部特性的測試與脫氮模型的研究, 2005/01-2007/12，結題，參加

獎勵與榮譽

2015年 清華大學環境學院學生工作先進個人

2014年 入選“清華大學桑坦德銀行資助項目”

2014年《污水處理在線監測儀器原理與應用(第二版)》獲得“2014年中國石油和化學工業優秀出版物獎·圖書獎”二等獎(排名第二)

2013年 微量有毒污染物快速高靈敏檢測的生物傳感技術及儀器，教育部技術發明獎一等獎，排名第六

2011年 教育部“長江學者和創新團隊發展計劃”創新團隊，成員

2010年 第七屆中國環境科學學會“優秀青年科技獎”

2009年 入選清華大學骨干人才計劃

2009年 “清華大學優秀博士后”稱號

學術成果

同行評議SCI期刊論文(*通訊作者)

1. Ruoyu Wang, Xiaohong Zhou*, Bo Liedberg, Xiyu Zhu, Abdul Ghaffar Memon, Hanchang Shi. Screening Criteria for Qualified Antibiotic Targets in Unmodified Gold Nanoparticles-Based Aptasensing, ACS Appl. Mater. Interfaces, 2017, 9, 35492–35497.

2. Xiyu Zhu, Ruoyu Wang, Xiaohong Zhou*, Hanchang Shi. Free-Energy-Driven Lock/Open Assembly-Based Optical DNA Sensor for Cancer-Related microRNA Detection with a Shortened Time-to-Result, ACS Appl. Mater. Interfaces 2017, 9, 25789-25795.

3. Lanhua Liu, Xiaohong Zhou*, Yun Lu*, Didi Shan, Bi Xu, Miao He, Hanchang Shi, Yi Qian. Facile screening of potential xenoestrogens by an estrogen receptor-based reusable optical biosensor. Biosensors and Bioelectronics, 2017, 97: 16-20

4. Lanhua Liu, Xiaohong Zhou*, James S. Wilkinson, Ping Hua*, Baodong Song, Hanchang Shi. Integrated optical waveguide-based fluorescent immunosensor for fast and sensitive detection of microcystin-LR in lakes: optimization and analysis. Scientific Reports. 2017, 7: 3655, DOI:10.1038/s41598-017-03939-8

5. Ruoyu Wang, Xiaohong Zhou*, Xiyu Zhu, Chao Yang, Lanhua Liu, Hanchang Shi. Isoelectric bovine serum albumin: Robust blocking agent for enhanced performance in optical-fiber based DNA sensing. ACS Sensors. 2017, 2(2): 257–262

6. Abdul Ghaffar Memon, Xiaohong Zhou*, Jinchuan Liu, Ruoyu Wang, Lanhua Liu, Bofan Yu, Miao He*, Hanchang Shi. Utilization of unmodified gold nanoparticles for label-free detection of mercury (II): Insight into rational design of mercury-specific oligonucleotides. Journal of Hazardous Materials. 2017, 321, 417-423.

7. Lanhua Liu, Xiaohong Zhou*, Mifang Lu, Mingkai Zhang, Chao Yang, Ruiman Ma, Abdul Ghaffar Memon, Hanchang Shi, Yi Qian. An fluorescent biosensor based on planar waveguide for multi-analyte determination in water samples. Sensors and Actuators B: Chemical. 2017, 240, 107-113.

8. Yijun Li, Cheng Wang, Yibo Zhu, Xiaohong Zhou, Yu Xiang, Miao He, Siyu Zeng. Fully integrated grapheme electronic biosensor for label-free detection of lead (II) ion based on G-quadruplex strcture-switching, Biosensors and Bioelectronics, 2017, 89: 758-763

9. Cheng Wang, Yijun Li, Yibo Zhu, Xiaohong Zhou, Qiao Lin, Miao He. High-k solid-gate transistor configured graphene biosensor with fully integrated structure and enhanced sensitivity. Advanced Functional Materials. 2016, 26, 7668–7678

10. Ruoyu Wang, Xiaohong Zhou*, Hanchang Shi, Yi Luo. T-T mismatch-driven biosensor using triple functional DNA-protein conjugates for facile detection of Hg2+. Biosensors and Bioelectronics. 2016, 78, 418-422.

11. Li-pei Zhang, Yun-peng Xing, Lan-hua Liu, Xiao-hong Zhou*, Han-chang Shi*. Fenton reaction-triggered colorimetric detection of phenols in water samples using unmodified gold nanoparticles. Sensors and Actuators B: Chemical, 2016, 225, 593-599.

12. Zhang Jing, Dong Qian, Liu Yanchen, Zhou Xiaohong*, Shi Hanchang. Response to shock load of engineered nanoparticles in an activated sludge treatment system: Insight into microbial community succession. Chemosphere. 2016, 144, 1837-1844.

13. Guo Hongli, Zhou Xiaohong, Zhang Yan, Song Baodong, Zhang Jingxuan, Shi Hanchang. Highly sensitive and simultaneous detection of melamine and aflatoxin M1 in milk products by multiplexed planar waveguide fluorescence immunosensor (MPWFI). Food Chemistry. 2016, 197, 359-366.

14. Han Shitong, Zhou Xiaohong, Tang Yunfei, He Miao, Zhang Xinyu, Shi Hanchang, Xiang Yu. Practical, highly sensitive, and regenerable evanescent-wave biosensor for detection of Hg2+ and Pb2+ in water. Biosensors and Bioelectronics. 2016, 80, 265-272.

15. Gu Chunmei, Long Feng, Zhou Xiaohong, Shi hanchang. Portable detection of Ochratoxin A in red wine based on a structure-switching aptamer using a personal glucometer. RSC Advances, 2016, 6, 29563.

16. Guo Hongli, Zhou Xiaohong, Zhang Yan, Gu Chunmei, Song Baodong, Shi Hanchang. Kinetic analysis of a high-affinity antibody/antigen interaction performed by planar waveguide fluorescence immunosensor. RSC Advances. 2016, 6, 13837.

17. Wang Ruoyu, Zhou Xiaohong*, Shi Hanchang. Triple functional DNA-protein conjugates: Signal probes for Pb2+ using evanescent wave-induced emission. Biosensors and Bioelectronics. 74 (2015) 78-84.

18. Liu Lan-hua, Zhou Xiao-hong*, Shi Han-chang. Portable optical aptasensor for rapid detection of mycotoxin with a reversible ligand-grafted biosensing surface. Biosensors and Bioelectronics. 72 (2015) 300-305.

19. Hao Xiu-juan, Zhou Xiao-hong*, Zhang Yan, Long Feng, Song Lei, Shi Han-chang. Portable and reusable optofluidics-based biosensing platform for ultrasensitive detection of sulfadimidine in dairy products. Sensors, 15 (2015) 8302-8313.

20. Li-pei Zhang, Yun-peng Xing, Chun Liu, Xiao-hong Zhou*, Han-chang Shi*. Label-free Colorimetric Detection of Cu2+ Based on Fenton Reaction Assisted Signal Amplification with Unmodified Gold Nanoparticles as Indicator. Sensors and Actuators B: Chemical, 215 (2015) 561-567.

21. Wang Ruoyu, Xiang Yu, Zhou Xiaohong*, Liu Lanhua, Shi Hanchang. A Reusable Aptamer-based Evanescent Wave All-fiber Biosensor for Highly Sensitive Detection of Ochratoxin A. Biosensors and Bioelectronics. 66 (2015) 11–18.

22. Zhou Xiao-hong*, Huang Bao-cheng, Zhou Tao, Liu Yan-chen, Shi Han-chang. Aggregation behaviour of engineered nanoparticles and their impact on activated sludge in wastewater treatment. Chemosphere. 119 (2015) 568–576.

23. Xing Yun-peng, Liu Chun, Zhou Xiao-hong*, Shi Han-chang. Label-free detection of kanamycin based on a G-quadruplex DNA aptamer-based fluorescent intercalator displacement assay. Scientific Reports. 5(2015) 8125.

24. Xing Yun-peng, Liu Chun, Zhou Xiao-hong*, Zhang Li-pei*, Shi Han-chang. Sensing of Cu2+ Based on Fenton Reaction and Unmodified Gold Nanoparticles. Spectroscopy and Spectral Analysis. (2015) 35(11):3151-3154.

25. Yanchen Liu, Chen Wu, Xiaohong Zhou, Hanchang Shi, D.Z. Zhu. Study on the sulfide elimination by intermittent nitrate dosing in sediments of sewer system. Journal of Environmental Science, 2015, 27(1): 259-265.

26. Yanchen Liu, Qian Dong, Chen Wu, Xiaohong Zhou, Hanchang Shi, Study of the succession of microbial communities for sulfur cycle response to ecological factors change in sediment of sewage system. Environmental science and pollution research international. 01/2015.

27. Liu Lan-hua, Zhou Xiao-hong*, Xu Wei-qi, Song Bao-dong, Shi Han-chang. Highly sensitive detection of sulfadimidine in water and dairy products by means of an evanescent wave optical biosensor. RSC Advances. 2014, 4, 60227–60233.

28. Hao Xiu-juan, Zhou Xiao-hong*, Zhang Yan, Liu Lan-hua, Long Feng, Song Lei*, Shi Han-chang. Melamine detection in dairy products by using a reusable evanescent wave biosensor. Sensors and Actuators B: Chemical, 2014, 204: 682–687.

29. Zhou Xiao-hong1, Song Bao-dong1, Shi Han-chang, Liu Lan-hua, Guo Hong-li, He Miao. An evanescent wave multi-channel immunosensor system for the highly sensitive detection of small analytes in water samples. Sensors and Actuators B: Chemical. 2014, 198: 150-156. (1Contributed equally)

30. Zhou Xiao-hong*, Liu Lan-hua, Xu Wei-qi, Song Bao-dong, Sheng Jian-wu, He Miao, Shi Han-chang*. A reusable evanescent wave immunosensor for highly sensitive detection of bisphenol A in water samples. Scientific reports. 2014, 4: 4572.

31. Song Lei, Zhu Lei, Liu Yan-chen, Zhou Xiao-hong*, Shi Han-chang. A disposable cobalt-based phosphate sensor based on screen printing technology. Science China Chemistry, 2014, 57(9): 1283-1290.

32. Guo Hong-li, Zhou Xiao-hong, Zhang Yan, Shi Han-chang. Highly sensitive and rapid detection of melamine in milk products by planar waveguide fluorescence immunosensor (PWFI). Sensors and Actuators B: Chemical, 2014, 194: 114-119.

33. Zhu Lei, Zhou Xiaohong, Shi Hanchang. A potentiometric cobalt-based phosphate sensor based on screen-printing technology. Frontiers of environmental science & engineering. 2014, 8(6): 945-951.

34. Feng Long, Anna Zhu, Xiaohong Zhou, Hongchen Wang, Zhen Zhao, Lanhua Liu, Hanchang Shi Highly sensitive and selective optofluidics-based immunosensor for rapid assessment of Bisphenol A leaching risk. Biosensors and Bioelectronics, 2014, 55: 19–2524.

35. Shi Han-Chang, Song Bao-Dong, Long Feng, Zhou Xiao-Hong, He Miao, Lv Qing, Yang Hai-Yang. Automated Online Optical Biosensing System for Continuous Real-Time Determination of Microcystin-LR with High Sensitivity and Specificity: Early Warning for Cyanotoxin Risk in Drinking Water Sources. Environmental science & technology, 2013, 47: 4434-41.

36. Xiao-Hong Zhou, Lan-Hua Liu, Xue Bai, Han-Chang Shi. A reduced graphene oxide based biosensor for high-sensitive detection of phenols in water samples. Sensors and Actuators B: Chemical, 2013, 181: 661-667.

37. Xiao-Hong Zhou, Ming-Kai Zhang, Tong Yu, Yan-chen Liu, Han-Chang Shi. Oxygen profiles in biofilms undergoing endogenous respiration. Chemical Engineering Journal, 2013, 220: 452-458.

38. Zhou Xiao-hong, Huang Xin-rui, Liu Lan-hua, Bai Xue, Shi Han-chang. Direct electron transfer reaction of laccase on 1-aminopyrene functionalized reduced graphene oxide. RSC Advances, 2013, 3: 18036-18043.

39. Zhou Xiaohong, Shi Hanchang, Song Yanqing, Wu Yuanyuan. Evaluation of oxygen transfer parameters of fine bubble aeration system in plug flow aeration tank of wastewater treatment plant. Journal of Environmental Sciences, 2013, 25: 295-301.

40. Zhou Xiao-Hong, Wang Xu-Ying, Shi Han-Chang. Inhibitory Effect of Nitrobenzene on Oxygen Demand in Lake Sediments. Journal of Environmental Sciences, 2012, 24(5): 1-6.

41. Liu Jing, Zhou Xiao-Hong*, Shi Han-Chang. Inhibitory effects of pentachlorophenol on wastewater biofilms as determined by phospholipid analysis and microelectrode. Biochemical Engineering Journal, 2012, 66: 8-13.

42. Zhou Xiao-Hong, Liu Jing, Song Hui-Min, Qiu Yu-Qin, Shi Han-Chang. Estimation of Heterotrophic Biokinetic Parameters in Wastewater Biofilms from Oxygen Concentration Profiles by Microelectrode. Environmental Engineering Science, 2012, 29(6): 466-471.

43. Zhou Xiao-Hong, Yu Tong, Shi Han-Chang, Shi Hui-Ming. Temporal and spatial inhibitory effects of zinc and copper on wastewater biofilms from oxygen concentration profiles determined by microelectrodes. Water Research, 2011, 45(2): 953-959.

44. Zhou Xiao-Hong, Qiu Yu-Qin, Shi Han-Chang, Yu Tong, He Miao, Cai Qiang. A new approach to quantify spatial distribution of biofilm kinetic parameters by in situ determination of Oxygen Uptake Rate (OUR). Environmental Science & Technology, 2009, 43: 757-763.

45. Zhou Xiao-Hong, Shi Han-Chang, Cai Qiang, He Miao, Wu Yin-Xi. Function of self-forming dynamic membrane and biokinetic parameters’ determination by microelectrode. Water Research, 2008, 42(10/11): 2369-2376.

46. Zhou Xiao-Hong, Shi Han-Chang*, Qiu Yu-Qin Inner-profiles of a spherical bio-carrier determined by microelectrodes. Biochemical Engineering Journal, 2008, 39(1): 28-36.

47. Zhou Xiao-Hong, Shi Han-Chang, Yu Tong. Characterization of a Spherical Packing Medium for Biological Nitrogen Removal by Microelectrodes. Environmental Engineering Science, 2008, 25(3): 375-382.

參編論著：

1. Chapter 6: An Evanescent Wave Fluorescent Immunosensor for Milk Quality Monitoring in the book of Food biosensor (ISBN: 9781782623618), Xiaohong Zhou, Hanchang Shi. Royal Society of Chemistry, 2016年8月.

2. 污水處理在線監測儀器原理與應用(第二版)[M]. 施漢昌，周小紅，劉艷臣. 化學工業出版社，2013年11月.

3. 微生物降解氯苯類化合物機理與應用[M]. 宋蕾，周小紅，白潤英. 化學工業出版社，2015年3月.

4. 生物接觸氧化法污水處理工程技術規范(HJ 2009-2011)，第五編著人.

授權及申報專利：

1. 檢測磷酸鹽的絲網印刷鈷傳感器的制備方法(第一/ZL 2008 1 0119649.X)

2. 一種多通道激光誘導熒光芯片(第一/ZL 2015 2 0364595.9)

3. 一種基于核酸適配體探針熒光傳感分析檢測待測樣本中的靶標物質的方法(第一/ZL 201410360025.2)

4. 一種抑制核酸分子對傳感界面非特異性吸附的封閉方法(第一/201610509843.3)

5. 一種用BSA等電點封閉液構建可再生DNA雜交界面的方法(第一/201610804155.X)

6. 一種DNA-蛋白質綴合物及其在檢測汞離子濃度中的應用(第一/ 201510780448.4)

7. 一種共軸型復合式氧微電極及其制備方法(第一/201510204564.1)

8. 一種檢測汞離子的熒光探針及其制備方法(第三/201510498609.0)

9. 一種檢測鄰苯二酚和/或對苯二酚的探針及方法(第三/201510695541.2)

10. 一種基于T-T錯配原理的飲用水中汞離子的熒光檢測方法(第三/201510490776.0)

11. 使檢測汞離子的生物芯片再生的成套試劑及其應用(第四/201510490778.X)

12. 一種制備核酸芯片的方法及其在倏逝波檢測中的應用(第五/201310336822.2)