中國藥科大學生命科學與技術學院研究生導師介紹：曹榮月

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曹榮月,碩士生導師，優秀本科生導師。中國生物化學與分子生物學會會員（S221020013M）。東南大學醫學院醫學遺傳學專業碩士畢業，中國藥科大學藥理學專業博士畢業。江寧大學城巡講講師，在中國藥科大學講授課程為藥學院各專業的生物化學與分子生物學、藥學院臨床藥學專業的醫學生物化學、中藥學院的生物化學以及分子生物學、專業英語、營養學的生物化學基礎等。近年來發表的各類論文60多篇，其中SCI論文30篇，其中在Journal of Immunology（影響因子6.2）、Endocrine-Related Cancer（影響因子5.8）、Vaccine（影響因子3.159）等較高影響因子雜志上發表有論文。參編教材三本，獲校教學成果一等獎一項，江蘇省教學成果獎一項，江蘇省科技進步獎一項。主持并完成三項江蘇省自然基金的項目，參與國家自然科學基金五項。申請國家專利并獲多項國家專利證書，2014年9月成功轉讓專利一項。現在研究方向為微生物與生化藥物研究與開發,重點在于抗腫瘤生物藥物以及腫瘤疫苗藥物的研究。

部分SCI文章：

[1]Xue JunWang & Li Jun Zhou & Xue Jiang Zhu & Kai Gu &Jie Wu & Tai Ming Li & Li Yuan & Rong Yue Cao. etection of antibodies against customized epitope: useof a coating antigen employing VEGF as fusion partner[J]. Appl Microbiol Biotechnol. 2014, 98:6659–6666

[2]X-h Sun, R-y Cao*, Y-x Wu, Y Liu, X-y Zhang. Ethanol thermal synthesis and antibacterial properties of Ag modified ZnO nanorods [J]. Materials Technology. 2014; 29( 2):105-111

[3] Jie Yang, Yanfei Xie, Huaqian Wang, Yi Yao, Jing Hou, Yanjun Ma, Qing Zhang, Yun Xing, Jie Wu, Taiming Li, Junnian Zheng, Jingjing Liu, Rongyue Cao. Administration of heat shock protein 65 inhibits murine melanoma growth in vivo [J]. Molecular Medicine Reports,2013;7(1):171-176.

[4] Yang Jie,Zhang Yankai,Wang Huaqian,Gao Zhenqiu,Wang Zeyu,Liu Bin,Zhang Xiuhua,Du Mingzhu,Huang Xiao,Xu Maolei,Wu Jie,Li Taiming,Liu Jingjing,Cao Rongyue.Vaccination with the repeat [beta]-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects[J].Tumor Biology,2012;33(5):1777-1784.

[5] Long Jun, Lin Jie, Yuan Dongpingc, Yang Xin, Li Taiming, Cao Rongyue, Wu Jie,  Liu Jingjing.Effects of nasal immunization of multi-target preventive vaccines on atherosclerosis[J].Vaccine ,2012;30(6):1029-1037.

[6] Long Jun, Lin Jie, Yang Xin, Yuan Dongping, Wu Jie, Li Taiming, Cao Rongyue, Liu Jingjing, Nasal immunization with different forms of heat shock protein-65 reduced high-cholesterol-diet-driven rabbit atherosclerosis[J]. International Immunopharmacology,2012;375(1):172-9.

[7] Ge C, Xing Y, Wang Q, Xiao W, Lu Y, Hu X, Gao Z, Xu M, Ma Y, Cao R, Liu J.Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432[J].Int Immunopharmacol. 2011;11(12):2200-7.

[8] Xiangbing H, Yankai Z, Ming L, Yong L, Yu Z, Huiyong Z, Yingying C, Jing H, Yun X, Liang J, Rongyue C, Jingjing L. The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma[J]. International Immunopharmacology, 2010 ;10(2):230-238.

[9] Yong L, Huiyong Z, Jing H, Huaqian W, Xiangbing H, Yanjun M, Xiaoyu G, Li H, Yanan Y, Rongyue C, Hao F, Jingjing L, Jie W. Vaccination with a potent DNA vaccine targeting B-cell epitopes of hGRP induces prophylactic and therapeutic antitumor activity in vivo[J]. Gene Ther. 2010; 17(4):459-68.

[10] Wang XJ, Gu K, Xu JS, Li MH, Cao RY, Wu J, Li TM, Liu JJ. Immunization with a recombinant GnRH vaccine fused to heat shock protein 65 inhibits mammary tumor growth in vivo[J]. Cancer Immunol Immunother, 2010;59(12):1859-66.

[11] Jean Louis Didier MEKOO, Yanan YANG, Taiming Li, Rongyue CAO, Jingjing LIU. Molecular Cloning and Expression of a Synthetic Gene Encoding a β-glucosidase of Aspergillus Nigerin the Methylotrophic Yeast Pichia Pastoris[J]. International Journal of Biology. 2010;2(2):40-49.

[12] Yong Lu, Didier Mekoo, Ouyan Kedong, Xiangbing Hu, Yanhua Liu, Ming Lin, Liang Jin, Rongyue Cao, Taiming Li, Zhang Yankai, Hao Fan and Liu Jingjing. Strong humeral response elicited by a DNA vaccine targeting gastrin-releasing peptide with optimized adjuvant inhibits murine prostate carcinoma growth in vivo[J]. Endocrine-Related Cancer, 2009;DOI: 10.1677/ERC-09-0058.

[13] Yong Lu, Zhang Huiyong, Fang Jing, Wang Huaqian, You Kejun, Yang Yanan, Liu Suli, Wang Xuejun, Meng Yuhan, Cao Rongyue, Fan Hao, Li Taiming, Liu Jingjing.Study on preparation and unique properties of a novel insulin analogue with N-terminal Arg-4, Pro-3, Lys-2, and Pro-1extension at insulin B-chain[J]. Regulatory Peptides, Oct 2009; 157(1-3): 92-98.

[14] Yong Lu, Kedong Ouyang, Guojun Wu, Jing Fang, Huiyong Zhang, Yanhua Liu, Yingying Chen, Ming Lin, Huaqian Wang, Liang Jin, Rongyue Cao, Rouel S. Roque, Li Zong, Jingjing Liu, and Taiming Li.Specific antibodies elicited by a novel DNA vaccine targeting gastrin-releasing peptide inhibit murine melanoma growth in vivo[J]. Clin Vaccine Immunol,2009; 16(7):1033-1039.

[15] Yong Lu, Kedong Ouyang, Jing Fang, Huiyong Zhang, Guojun Wu, Yanjun Ma, Yu Zhang, Xiangbing Hu, Liang Jin, Rongyue Cao, Hao Fan, Taiming Li, Jingjing Liu.Improved efficacy of DNA vaccination against prostate carcinoma by boosting with recombinant protein vaccine and by introduction of a novel adjuvant epitope[J]. Vaccine, 2009; 27(39): 5411-8.

[16] Xiong Qiyan, Jin Liang, Li Jianping, Fan Hao, Cao Rongyue, Wu Jie, Li Taiming and Liu Jingjing. A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies[J]. Autoimmunity, 2009; 42(6): 475–483.

[17] Jiao Feng, Yanhua Liu, Yun Xing, Huaqian Wang, Taiming Li, Jingjing Liu, Hao Fan, Rongyue Cao. A novel human parathyroid hormone (1-34) analog for the treatment of Osteoporosis.[J]Peptides, 2009; 30(6):1173-80.

[18] Huaqian Wang, Jie Yang, Liang Jin, Jiao Feng, Yong Lu, Yunxiao Sun, Taiming Li, Rongyue Cao, Jie Wu, Hao Fan, and Jingjing Liu*. Immunotherapy of Autoimmune Diabetes by Nasal Administration of Tandem Glutamic Acid Decarboxylase 65 Peptides [J]. Immunological Investigations.2009;38(8):690-703.

[19] Xue Jun Wang*, Kai Gu, Qi Yan Xiong, Liang Shen, Rong Yue Cao, Ming Hui Li, Tai Ming Li, Jie Wu*, Jing Jing Liu. A novel virus-like particle based on hepatitis B core antigen and substrate-binding domain of bacterial molecular chaperone DnaK [J]. Vaccine. 2009; 27(52):7377-7384.

[20] Yunxiao Sun，Zhufang Li，Xin Yang; Jun Long; Qiyan Xiong，Gaofu Qi，Rongyue Cao, Jie Wu, Jingjing Liu, Hao Fan, Taiming Li. Construction, Expression,Purification and Immunology Effect of an Antiatherosclerosis Chimeric Enzyme Vaccine in Escherichia coli[J]. Protein & Peptide Letters, 2008;15:745-52.

[21] Wu Guojun, Guo Wei, Ouyan Kedong, He Yi, Xie Yanfei, Chen Qingmei, Zhang Yankai, Wu Jie, Fan Hao, Li Taiming, Liu Jingjing and Cao Rongyue. Novel vaccine targeting gastrin-releasing peptide: Efficient inhibition of breast cancer growth in vivo [J].Endocr Relat Cancer, 2008; 15(1):149-59.

[22] Liang Jin, Aihua Zhu, Yu Wang, Qingmei Chen, Qiyan Xiong, Jianping Li, Yunxiao Sun, Taiming Li, Rongyue Cao, Jie Wu and Jingjing Liu. A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice [J]. J Immunol, 2008; 180(1):58-63.

[23] Liang Jin, Yu Wang, Qiyan Xiong, Qingmei Chen, Jianping Li, Aihua Zhu, Rongyue Cao, Jie Wu, Jingjing Liu. Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants [J]. Vaccine, 2007; 25(11):2043-50.

[24] Zhang Yankai, Yan Rong, He Yi, Liu Wentao, Cao Rongyue, Yan Ming, Li Taiming, Liu Jingjing, Wu Jie. Ten tandem repeats of beta-hCG 109-118 enhance immunogenicity and anti-tumor effects of beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65[J]. Biochem Biophys Res Commun, 2006; 345(4):1365-71.

[25] Dan Mao, Gu Kai, Qi Gaofu, Zhu Zheng, Zhong Li, Wu Jie, Liu Jingjing, Cao Rongyue. Intramuscular immunization with a DNA vaccine encoding a 26-amino acid CETP epitope displayed by HBc protein and containing CpG DNA inhibits atherosclerosis in a rabbit model of atherosclerosis[J].Vaccine, 2006; 24(23):4942-50.

[26] Gaofu Q, Rongyue C, Dan M, Xiuyun Z, Xuejun W, Jie W, Jingjing L.Asparaginase display of human cholesteryl ester transfer protein (CETP) B cell epitopes for inducing high titers of anti-CETP antibodies in vivo[J].Protein Pept Lett, 2006; 13(2):149-54.

[27] He Yi, Yan Rong, Zhang Yankai, Liu Wentao, Zhou Hongxia, Wu Jie, Cao Rongyue, Li Taiming, Liu Jingjing. Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein HSP65 [J]. Vaccine, 2006; 24(14):2575-84.

[28] Xu Jinshu, Liu Jingjing, Peng Duan, Zhu Zheng, Ming Ding, Wu Jie, Cao Rongyue, Hu Zhuoyi, Rouel S. Roque . A synthetic gonadotropin-releasing hormone (GnRH) vaccine for control of fertility and hormone dependent diseases without any adjuvant[J].Vaccine, 2005; 23(40):4834-43.

[29] Gaofu Q, Jie L, Rongyue C, Xin Y, Dan M, Jie W, Xiangchun S, Qunwei X, Roque RS, Xiuyun Z, Jingjing L. Asparagines display of polypeptides in the periplasm of Escherichia coli: Potential rapid pepscan technique for antigen epitope mapping [J]. J Immunol Methods, 2005; 299(1-2):9-19.

[30] Xu Jinshu, Liu Jingjing, Peng Duan, Zhu Zheng, Ming Ding, Wu Jie, Cao Rongyue, Hu Zhuoyi. The immunogenicity of recombinant and dimeric gonadotrophin-releasing hormone vaccines incorporating a T-helper epitope and GnRH or repeated GnRH units [J].J Immunol Methods, 2004; 289(1-2):111-22.

獲得的部分國家專利：

（1）能通過免疫防治Ⅰ型糖尿病的重組蛋白和重組基因

（2）HSP65重組蛋白質的制備及用途

（3）一種抗動脈粥樣硬化的表位組合物、其制備方法及用途

（4）一種免佐劑具有防治Ⅰ型糖尿病作用的免疫調節劑

（5）人胰島素類似物的制備方法及用途

（6）一種能串聯表達和同步酸水解釋放的人甲狀旁腺素1-34肽類似物及其制備方法和應用

（7）一種新型血管內皮細胞疫苗及其制備方法

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