中國藥科大學中藥學院研究生導師介紹：余伯陽

導師信息來源：中國考研網 2016-07-13　相關院校：中國藥科大學

余伯陽，男，1959年3月生，教授、博士生導師。現任中國藥科大學研究生院常務副院長；江蘇省中西醫結合一級學科重點學科學科帶頭人，江蘇省中藥評價與轉化重點實驗室主任。全國首批新世紀“百千萬人才工程”國家級人選，享受國務院頒發的政府特殊津貼的專家，江蘇省跨世紀學術帶頭人，江蘇省有突出貢獻的中青年專家，江蘇省"333人才工程"（第二層次）人選，霍英東教育基金會第五屆高等院校青年教師獎（研究類）獲得者，教育部高校優秀骨干教師。兼任國家藥典委員會委員，國務院學位委員會學科評議組成員，全國藥學專業學位研究生教育指導委員會秘書長，國家新藥審評專家，國家藥品價格評審專家，江蘇省政協常委等職務。

1989年畢業于中國藥科大學生藥學專業獲理學博士學位，導師為徐國均院士。1988年在日本昭和大學藥學部任客座研究員，1995年在美國伊利諾大學芝加哥分校藥學院從事博士后研究工作，1996年至1997年在美國依阿華大學藥學院任訪問教授。

研究方向與研究興趣：

1、中藥及復方藥效物質基礎及作用機理研究（中西醫結合基礎（藥學））：利用化學與生物學相結合的方式，探索構建物質基礎與作用機制綜合分析研究體系用于中藥復方的評價研究。建立了整合指紋圖譜等分析技術，開展多組分協同作用、毒效相關分析、體內外效應物質相關分析等研究；經典復方的組方原理與組方優化研究；源于療效確切的著名中成藥的組方優化與二次開發研究

主要研究成果：

先后承擔國家863重大新藥創制項目、國家自然科學基金重大專項、國家科技支撐計劃等研究項目30多項；研究成果曾獲國家科技進步一等、二等、三等獎各1項，教育部高等學校科學研究優秀成果獎二等獎（自然科學類）1項，省部級科技進步一等獎3項、二等獎3項。近年來，申請發明專利30多項，其中授權10多項，發表論文200多篇，其中SCI收錄100多篇。

聯系方式：

地址：南京市江寧大學城龍眠大道639號，中國藥科大學研究生院
郵編：211198
電話：025-86185157-8001；02586185287
郵箱：boyangyucpu@163.com

近五年來發表的代表性學術論文：
1.Identification and Determination of the Major Triterpenes in RhizomaAlismatis by HPLC-Evaporative Light Scattering Detection and HPLC/Electrospray Ionization-MSn [J] Journal of AOAC International. 2013, 96(2): 260-264.
2.Effect of Kai Xin San on Learning and Memory in a Rat Model of Paradoxical Sleep Deprivation [J]. Journal of medicinal food. 2013, 16(4): 280-287.
3.A facile drug delivery system preparation through the interaction between drug and iron ion of transferring [J]. Journal of Nanoparticle Research. 2013, 15(9): 1-12.
4.Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. [J] International Immunopharmacology, 2013, 15: 240-245.
5.Screening and identifying the myocardial-injury protective ingredients from Sheng-Mai-San. Pharmaceutical Biology, 2013, 51(10): 1219-1227.
6.Ruscogenin reduces cerebral ischemic injury via NF-κB-mediated inflammatory pathway in the mouse model of experimental stroke. European Journal of Pharmacology, 2013, 714: 303-311.
7.Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: Involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. Int Immunopharmacol. 2012, 12(1): 88-92.
8.Regio- and enantio- selective glycosylation of tetrahydroprotoberberines by Gliocladium deliquescens NRRL1086 resulting in unique alkaloidal glycosides. Appl Microbiol Biot, 2012, 93: 2357–2364.
9.Antioxidant anthocyanins screening through spectrum–effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem, 2012, 132: 759–765.
10.Efﬁcient synthesis of Guanfu base G via highly regioselective lipase-catalyzed acylation in non-aqueous phase. Bioorg Med Chem Lett.2012, 22(9): 3100-3103.
11.Ginsenoside Rg1 protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int, 2011, 58(1): 119-125.
12.Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily. Food Chem Toxicol, 2011, 49(9): 2243-2251.
13.New approaches to the structural modification of olean-type pentacylic triterpenes via microbial oxidation and glycosylation. Tetrahedron, 2011, 67(23): 4206-4211.
14.On-line high-performance liquid chromatography–diode detection–electrospray ionization–mass spectrometry–chemiluminescence assay of radical scavengers in Epimedium. J Chromatogr A, 2011, 121(9): 1227-1235.
15.Two new benzofuran derivatives with anti-inﬂammatory activity from Liriope spicata var. prolifera. Fitoterapia, 2011, 82(2): 190–192.
16.Identiﬁcation of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS. J Pharmaceut Biomed,2011,54 (5): 1110–1127.
17.Ruscogenin Mainly Inhibits Nuclear Factor-κB but Not Akt and Mitogen-Activated Protein Kinase Signaling Pathways in Human Umbilical Vein Endothelial Cells. J Pharmacol Sci, 2010,113(4): 409 – 413.
18.A new sol–gel silica nanovehicle preparation for photodynamic therapy in vitro. Int J Pharmaceut, 2010, 386(12): 131–137.
19.Effects of Storage Condition Factors on Fungal Invasion of Radix Ophiopogonis. J Agric Food Chem, 2010, 58(9): 5432-5437.
20.Homoisoﬂavonoids from the Fibrous Roots of Polygonatum odoratum with Glucose Uptake-Stimulatory Activity in 3T3-L1 Adipocytes. J Nat Prod, 2010, 73(4): 548–552.
21.One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity. Bioorg Med Chem Lett, 2010, 20(14): 4015-4017.
22.Quality and antioxidant activity detection of Crataegus leaves using on-line high-performance liquid chromatography with diode detector coupled to chemiluminescence detection. Food Chem, 2010, 120(3): 929-933.
23.Microbial conversion of ruscogenin by Gliocladium deliquescens NRRL1086: glycosylation at C-1. Appl Microbiol Biot, 2010, 86(2): 491-497.
24.Isolation and Anti-Inflammatory Activity Evaluation of Triterpenoids and a Monoterpenoid Glycoside from Harpagophytum procumbens. Planta Med, 2010, 76(16): 1892–1896.
25.Biotransformation of Bioactive Natural Products for Pharmaceutical Lead Compounds. Curr Org Chem, 2010, 14(14): 1400-1406.
26.Quality control of flavonoids in Ginkgo biloba leaves by high-performance liquid chromatography with diode detection and on-line radical scavenging activity detection. J Chrom. A, 2009,1216: 2204–2210
27.The antioxidant-activity-integrated fingerprint: An advantageous tool for the evaluation of quality of herbal medicines. J Chromatogr A. 2008, 1208(1-2):76-82
28.Evaluation of the analgesic and anti-inflammatory activities of Liu-Shen-Wan and its individual fractions in mice. J Ethnopharmacol., 2007,117:108-114
29.Determination of glycyrrhizin in Chinese prescriptions and biological samples by enzyme-linked immunosorbent assay. Analytica Chimica Acta 2006; 564（2）：173-178
30.Novel biotransformation of pentacyclic triterpenoid acids by Nocardia sp. NRRL 5646. Tetrahedron Letter,2005,46,2337-2340