中國藥科大學藥學院研究生導師介紹：張廣欽

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張廣欽,男，博士，副研究員，碩士生導師。

E-mail:njzhanggq@163.com

025-83271070(辦)

受教育經歷：

2001/10-2003/10，北京大學，生命科學學院，博士后
1997/09-2001/06,中國藥科大學,藥學院，博士
1989/09-1992/06,中國藥科大學,藥學院，碩士
1982/09-1985/06,河南大學，藥學系

研究工作經歷：

2009/10-2010/11，新加坡國家心臟中心，研究科學家
2005/01-2006/01，香港科技大學，生化系，博士后
2001/10-2003/10，北京大學，生命科學學院，博士后
2004/11-目前，中國藥科大學,藥學院，副研究員
1992/07-2001/09，中國藥科大學,藥學院，講師
1985/8-1989/8，河南商丘地區中醫院，藥劑師

主要研究領域：

1.心肌和神經細胞離子通道研究以及細胞鈣信號轉導。
2.誘導性多潛能干細胞(iPS)定向心肌細胞分化的研究。

近幾年發表的主要論文：

1.Zhang GQ, Wei H, Lu J, Wong P, Shim W. Identification and characterization of calcium sparks in cardiomyocytes derived from human induced pluripotent stem cells. PLoS One. 2013;8(2):e55266.
2.Wei H, Zhang G, Qiu S, Lu J, Sheng J, Manasi, Tan G, Wong P, Gan SU, Shim W. Hydrogen sulfide suppresses outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes. PLoS One. 2012;7(11):e50641.(并列作者).
3.Ma D, Wei H, Lu J, Ho S, Zhang G, Sun X, Oh Y, Tan SH, Ng ML, Shim W, Wong P, Liew R. Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J. 2013；34(15):1122-33..
4.Shim W, Mehta A, Lim SY, Zhang G, Lim CH, Chua T, Wong P. G-CSF for stem cell therapy in acute myocardial infarction: friend or foe? Cardiovasc Res. 2011;89(1):20-30.
5.Zhang GQ, Qiu SH, Wei HM.Scutellarin blocks sodium current in freshly isolated mouse hippocampal CA1 neurons. Neurochem Res. 2011, 36:947-54.
6.Zhang GQ, Wang H, Liu WT, Dong H, Fong WF, Tang LM, Xiong YH, Yu ZL, Ko KM. Long-Term Treatment with a Chinese Herbal Formula, Sheng-Mai-San, Improves Cardiac Contractile Function in Aged Rats: The Role of Ca2+ Homeostasis.Rejuvenation Res. 2008, 11: 991-1000.
7.Zhang GQ, Huang XD, Wang H, Leung AK, Chan CL, Fong DW, Yu ZL. Anti-inflammatory and analgesic effects of the ethanol extract of Rosa multiflora Thunb. hips. J Ethnopharmacol. 2008;118:290-4.
8.Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ. Temperature dependence and thermodynamic properties of Ca2+ sparks in rat cardiomyocytes. Biophys J. 2005;89:2533-41
9.Zhang Guangqin, Fu Yu, Yang Dongmei, Hao Xuemei, Bai Shuhua, Tang Yiqun, Edward G Lakatta, Cheng Heping. Contribution of Spontaneous L-type Ca2+ channel activation to the genesis of Ca2+ sparks in resting cardiac myocyte. Science in China (C) 2004;47(1):31-8
10. ZHANG Guang-Qin, HAO Xue-Mei, DAI De-Zai, FU Yu, ZHOU Pei-Ai, WU Cai-Hong. Puerarin blocks Na+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin 2003; 24(12): 1212-6
11. ZHANG Guang-Qin, HAO Xue-Mei, CHEN Shi-Zhong, ZHOU Pei-Ai, CHENG He-Ping, WU Cai-Hong. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 2003; 24(12):1248.-52
12. G-Q Zhang, X-M Hao, P-A Zhou, C-H Wu. Effect of paeonol on L-type calcium channel in rat ventricular myocytes. Mothods Find Exp Clin Pharmacol 2003; 25(4):281-5
 13. ZHANG Guang-Qin, HAO Xue-Mei, ZHOU Pei-Ai, WU Cai-Hong, DAI De-Zai.Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. Acta Pharmacol Sin 2001; 22(3):253-6.
14. Zou L.Y., Hao X.M., Zhang G.Q., Zhang M., Guo J.H., Liu T.F.: Effect of Tetramethyl Pyrazine on L-type Calcium Channel in Rat Ventricular Myocytes. Can. J. Physiol. Pharmacol 2001; 79: 621-6.

參與國家級科研項目：

1．心律失常離子通道病變特征ERG基因表達及突變。國家自然科學基金資助項目。NO：39870088
2．改造槲皮素及葛根素優化組合治療缺血性心律失常的活性。國家自然科學基金資助項目。NO：39970850
3．鈣火花與心臟衰老及鈣火花學中若干基本問題的研究。國家重點基礎研究發展規劃資助項目（973項目）。NO:G2000057002
4．鈣調蛋白調節心肌興奮－收縮耦聯的分子機制。NO:30200088

獲獎情況：

獲得2001年度中國高校科學技術獎自然科學二等獎
獲得2004年中華醫學科技獎三等獎