中國藥科大學(xué)藥學(xué)院研究生導(dǎo)師介紹：洪浩

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洪浩，博士，教授，博士生導(dǎo)師，教育部創(chuàng)新團(tuán)隊成員，江蘇省首席科技傳播專家，中國藥理學(xué)會神經(jīng)精神藥理專業(yè)委員會委員，中國藥理學(xué)會抗衰老與老年癡呆專業(yè)委員會委員，江蘇省藥理學(xué)會常務(wù)理事及教學(xué)專業(yè)委員會秘書長，“神經(jīng)藥理學(xué)報”編委，“Metabolic Brain Disease”（USA）編委。洪浩教授于1989年6月畢業(yè)于中國藥科大學(xué)，2001年6月獲安徽中醫(yī)學(xué)院醫(yī)學(xué)碩士學(xué)位，2004年6月獲中國藥科大學(xué)理學(xué)博士學(xué)位，2006年10月從KinkiUniversity（Japan）留學(xué)回國。近年來，承擔(dān)藥理學(xué)、當(dāng)代藥理學(xué)及表觀遺傳學(xué)等課程的教學(xué)工作；主持和參加國家自然科學(xué)基金面上項目、“十一五”和“十二五”國家“新藥創(chuàng)制”科技重大專項等多項國家及省部級科研項目；在國際知名雜志如Neurobiology of Aging，Int J Neuropsychopharmacol，Neuropharmacology，British J Pharmacol，J Neurochem等發(fā)表研究論文30余篇；申請國內(nèi)發(fā)明專利3項；參編著作1部。

研究方向：神經(jīng)藥理。采用分子遺傳學(xué)、細(xì)胞分子生物學(xué)及動物行為學(xué)等實(shí)驗(yàn)方法探尋介導(dǎo)阿爾茨海默病（AD）及相關(guān)疾病（如抑郁癥和糖尿病）發(fā)生發(fā)展的關(guān)鍵分子，確證其作為藥物調(diào)控的分子靶標(biāo)，并以此為基礎(chǔ)發(fā)掘活性物質(zhì)、開發(fā)防治藥物。當(dāng)前正在研究的課題有國家自然科學(xué)基金面上項目2項、“十二五”國家重大新藥創(chuàng)制項目1項以及江蘇省自然科學(xué)基金項目1項。

聯(lián)系方式：honghao@cpu.edu.cn;haohongchina@hotmail.com,025-86185227，83271157，江寧校區(qū)綜合研發(fā)樓551室。

近期已發(fā)表的代表性論文:

1. Miao-Jin Ji, Xu-Ben Yu, Zhen-Lin Mei, Yun-Qi An, Su-Su Tang, Mei Hu, Yan Long, Ming-Xing Miao, Qing-Hua Hu, Hong-Bin Sun, Ling-Yi Kong, and Hao Hong*. Hippocampal PPARδ overexpression or activation represses stress-induced depressive behaviors and enhances neurogenesis. Int J Neuropsychopharmacol. In Press.
2. Fang Chen, Rong Rong Dong, Kai Long Zhong, Arijit Ghosh, Su Su Tang, Yan Long, Mei Hu, Ming Xing Miao, Jian Min Liao, Hong Bing Sun, Ling Yi Kong, and Hao Hong*. Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice. Neuropharmacology. In Press.
3. Tang SS, Ji MJ, Chen L, Hu M, Long Y, Li YQ, Miao MX, Li JC, Li N, Ji H, Chen XJ, Hong H*. Protective effect of pranlukast on Aβ1-42-induced cognitive deficits associated with downregulation of cysteinyl leukotriene receptor 1. Int J Neuropsychopharmacol. 2014 ;17(4):581-92.
4. Tang SS, Hong H*, Chen L, Mei ZL, Ji MJ, Xiang GQ, Li N, Ji H. Involvement of cysteinyl leukotriene receptor 1 in Aβ1-42-induced neurotoxicity in vitro and in vivo. Neurobiol Aging. 2014;35(3):590-9.
5. Lai J, Hu M, Wang H, Hu M, Long Y, Miao MX, Li JC, Wang XB, Kong LY, Hong H*. Montelukast targeting the cysteinyl leukotriene receptor 1 ameliorates Aβ1-42-induced memory impairment and neuroinflammatory and apoptotic responses in mice. Neuropharmacology. 2014;79:707-14.
6. Wang H, Mei ZL, Zhong KL, Hu M, Long Y, Miao MX, Li N, Yan TH, Hong H*. Pretreatment with antiasthmatic drug ibudilast ameliorates Aβ1-42-induced memory impairment and neurotoxicity in mice. Pharmacol Biochem Behav. 2014；124:373–379.
7. Lai J, Mei ZL, Wang H, Hu M, Long Y, Miao MX, Li N, Hong H*. Montelukast rescues primary neurons against Aβ1-42-induced toxicity through inhibiting CysLT1R-mediated NF-κB signaling. Neurochem Int. 2014 ;75:26-31. (IF:2.659)
8．Du GT, Hu M, Mei ZL, Wang C, Liu GJ, Hu M, Long Y, Miao MX, Chang Li J, Hong H*.
Telmisartan treatment ameliorates memory deficits in streptozotocin-induced diabetic mice via attenuating cerebral amyloidosis. J Pharmacol Sci. 2014;124(4):418-26.
9. Tang SS, Wang XY, Hong H*, Long Y, Li YQ, Xiang GQ, Jiang LY, Zhang HT, Liu LP, Ji H. Leukotriene D4 induces cognitive impairment through enhancement of CysLT₁ R-mediated amyloid-β generation in mice. Neuropharmacology. 2013; 65:182-92. (IF:4.114)
10. Wang XY, Tang SS, Hu M, Long Y, Li YQ, Liao MX, Ji H, Hong H*. Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. Neurochem Int. 2013; 62(3):340-7.
11. Liu LP, Yan TH, Jiang LY, Hu W, Hu M, Wang C, Zhang Q, Long Y, Wang JQ, Li YQ, Hu M, Hong H*. Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation. Acta Pharmacol Sin. 2013; 34(4):455-63.
12. Xiang GQ, Tang SS, Jiang LY, Hong H*, Li Q, Wang C, Wang XY, Zhang TT, Yin L. PPARγ agonist pioglitazone improves scopolamine-induced memory impairment in mice. J Pharm Pharmacol. 2012; 64(4):589-96.
13. Jiang LY, Tang SS, Wang XY, Liu LP, Long Y, Hu M, Liao MX, Ding QL, Hu W, Li JC, Hong H*. PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci Ther. 2012; 18(8):659-66.