中國藥科大學藥學院研究生導師介紹：宋瑞

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宋瑞，女，1983年11月生，博士，副教授。2005年畢業于中國藥科大學中藥學專業，獲學士學位，2010年獲本校藥物分析博士學位并留校任教。

主持國家自然科學基金（81403314）、江蘇省自然科學基金(BK2012349)、中央高校基本科研培育項目（JKPZ2013008）。作為主要成員參加完成國家自然科學基金（30672587、30873439）、江蘇省基礎研究計劃（BK2006153）、國家中醫藥局中醫藥行業科研專項（200707008）等10余項國家及省部級科研項目。

研究方向：以現代色譜、光譜及其聯用技術為依托，開展基于多層次代謝分析的中藥配伍、炮制、中西藥聯用減毒增效機理研究。

聯系方式：songrui@cpu.edu.cn

研究成果：2005年至今共發表相關研究領域學術論文21篇，第一作者及通訊作者論文8篇，其中SCI論文7篇。

[1] Wang M, Fu J, Lv M, Tian Y, Xu F, Song R*, Zhang Z*.Effect of wine processing and acute blood stasis on the serum pharmacochemistry of rhubarb: A possible explanation for processing mechanism. Journal of Separation Science. 2014 Jun 30. doi: 10.1002/jssc.201400473.  IF: 2.594
[2] Rui Song, Ying Cheng, Yuan Tian, Zunjian Zhang*. A validated solid−phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction. Chinese Journal of Natural Medicines, 10(4): 0275-0278, 2012
[3] Rui Song, Lei Xu, Fengguo Xu, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatograpy-tandem mass spectrometry. Biomedical Chromatography, 25(3): 417-426, 2011. IF: 1.966
[4] Rui Song, Lei Xu, Fengguo Xu, Zhe Li, Hanjuan Dong, Yuan Tian, Zunjian Zhang*. In vivo metabolism study of rhubarb decoction in rat using high-performance liquid chromatography with UV photodiode- and mass spectrometric detection: a strategy for systematic analysis of metabolites from traditional Chinese medicines in biological samples. Journal of Chromatography A, 1217 (45): 7144-7152, 2010. IF: 4.194
[5] Rui Song, Lei Xu, Zunjian Zhang*, Yuan Tian, Fengguo Xu, Hanjuan Dong. Validated method for determination of gallic acid in rat plasma by liquid chromatography/tandem mass spectrometry. Chromatographia, 71(11/12): 1107-1111, 2010.IF: 1.075
[6] Rui Song, Fengguo Xu , Zunjian Zhang *, Ying Liu , Haijuan Dong, Yuan Tian. Structural elucidation of in vitro metabolites of Emodin by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography, 2008, 22(11):1230-1236. IF: 1.592
[7] Rui Song, Hui Lin, Zunjian Zhang*, Zhe Li, Lei Xu, Haijuan Dong, Yuan Tian. Profiling the metabolic difference of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition. Rapid Communications in Mass Spectrometry, 2009, 23(4):537-547.IF: 2.695