中國(guó)藥科大學(xué)藥學(xué)院研究生導(dǎo)師介紹：馮芳

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馮芳,藥物分析學(xué)博士，教授、博士生導(dǎo)師；教育部藥物質(zhì)量與安全預(yù)警重點(diǎn)實(shí)驗(yàn)室學(xué)術(shù)帶頭人。2000－2001年日本歧阜藥科大學(xué)藥學(xué)部高級(jí)訪問學(xué)者。

研究方向藥物質(zhì)量研究與評(píng)價(jià)

研究?jī)?nèi)容藥物質(zhì)量分析方法建立研究、藥物體內(nèi)過程分析研究、手性藥物拆分及體內(nèi)立體選擇性藥代動(dòng)力學(xué)研究、中藥（復(fù)方）藥效物質(zhì)基礎(chǔ)研究。

學(xué)術(shù)兼職國(guó)家藥典委員會(huì)委員、國(guó)家獸藥典委員會(huì)委員、國(guó)家藥監(jiān)局保健食品安全和技術(shù)規(guī)范專家委員會(huì)委員；國(guó)家科學(xué)技術(shù)獎(jiǎng)勵(lì)評(píng)審專家；國(guó)家藥監(jiān)局保健食品、化妝品、獸藥評(píng)審專家；國(guó)家科技專家?guī)煸趲?kù)專家；教育部高校同行評(píng)議專家；江蘇省新藥及保健食品審評(píng)專家。《藥物分析雜志》、《中國(guó)藥科大學(xué)學(xué)報(bào)》編委。

人才計(jì)劃及主要榮譽(yù)江蘇省“333高層次人才培養(yǎng)工程”首批中青年科學(xué)技術(shù)帶頭人；青藍(lán)工程江蘇省中青年學(xué)術(shù)帶頭人；“十五”國(guó)家級(jí)重點(diǎn)教材《藥物分析》編委、省一類精品課程主要成員；《有機(jī)光譜分析》（副主編）獲國(guó)家醫(yī)藥管理局科技進(jìn)步三等獎(jiǎng)；江蘇省優(yōu)秀研究生課程《藥物光譜分析選論》負(fù)責(zé)人；2007、2009、2010年江蘇省優(yōu)秀研究生論文導(dǎo)師，2010年、2012年圣和研究生創(chuàng)新成果二等獎(jiǎng)導(dǎo)師。

近年來科研工作：

1．國(guó)家自然科學(xué)基金項(xiàng)目負(fù)責(zé)人。

2．江蘇省科技廳科技支撐計(jì)劃項(xiàng)目負(fù)責(zé)人。

3．科技部重大新藥創(chuàng)制項(xiàng)目子課題負(fù)責(zé)人。

4．企業(yè)委托新藥質(zhì)量研究、體內(nèi)過程分析研究、代謝產(chǎn)物分析研究等項(xiàng)目負(fù)責(zé)人。

近年來代表性論文、論著：

1.An untargeted metabolomics-driven approach based on LC–TOF/MS and LC–MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2015,115: 315–322 .

2.An effective integrated method for comprehensive identification of eighty-five compounds in Zhi-Zi-Da-Huang decoction by HPLC-DAD-ESI-MS (TOF) and HPLC-DAD-ESI-MS/MS (QqQ) without the help of reference standards. Analytical method. 2014, 6:4312-4327.

3.Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015, 1- 6.

4.Optimization of the separation and determination of nitidine and chelerythrine in zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 , 52(2):164-168.

5.Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: restoration of monoamine neurotransmitters in discrete brain regions. Pharm Biol. 2013, 51(2):213-20.

6.A  highly sensitive nonenzymatic glucose sensor based on CuO nanowires. Microchim Acta. 2012, 176:411-417.

7.Pharmacokinetics of Geniposide in Zhi-Zi-Hou-Pu Decoction and in Different Combinations of its Constituent Herbs. Phytotherapy Research. 2012, 26: 67-72

8.Pyrosequencing on nicked dsDNA generated by nicking endonucleases. Analytical Chemistry. 2010, 82(5):2074-81.

9.Determination of selected elements in aqueous extractions of a traditional Chinese medicine formula by ICP-MS and FAAS: evaluation of formula rationality. Analytical Letters, 2010, 43: 983-992.

10.Identification of components in Zhi-Zi-Da-Huang decoction by HPLC coupled with electrospray ionization tandem mass spectrometry, photodiode and fluorescence detectors. Journal of Pharmaceutical and Biomedical Analysis,.2009, 49, 1157-1165.

11.Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats. Journal of Ethnophamacology. 2009, 126, 273-279.

12.Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method. Journal of Pharmaceutical Science. 2009, 98(2):728-38.

13.Development of a new pre-derivatization LC method for analysis of branched-chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a result of acute hepatic injury. Chromatographia, 2009, 70, 57-65.

14.主編《藥物分析》，東南大學(xué)出版社，2011年。

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