中國藥科大學(xué)藥學(xué)院研究生導(dǎo)師介紹：薛曉文

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簡歷：薛曉文，中國藥科大學(xué)藥物化學(xué)教研室副教授。2005年獲美國邁阿密大學(xué)化學(xué)系有機(jī)化學(xué)專業(yè)博士學(xué)位(Ph.D.)，2005-2006年美國邁阿密大學(xué)化學(xué)系博士后。目前主要從事藥物化學(xué)以及有機(jī)合成領(lǐng)域的研究，在國外雜志發(fā)表了多篇SCI論文，同時申請中國發(fā)明專利數(shù)項(xiàng)。

研究方向：具有抗纖維化或抗腫瘤活性的天然產(chǎn)物的合成、結(jié)構(gòu)修飾及活性評價；藥物新合成路線的設(shè)計與開發(fā)。

主要論著：

1.Dongsheng Chen, Yaping Song, Yunlong Lu, and Xiaowen Xue*, “Synthesis and in vitro cytotoxicity of andrographolide-19-oic acid analogues as anti-cancer agents”, Bioorg. & Med. Chem. Lett. 2013, 23, 3166-3169.
2.Qiao Sun, Yiwu Yao, Chunping Liu, Hua Li, Hequan Yao, Xiaowen Xue, Jinsong Liu, Zhengchao Tu, Sheng Jiang, “Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry”, Bioorg. & Med. Chem. Lett. 2013, 23, 3295-3299.
3.Lutai Wang，Jiabin Li, Xiaowen Xue*, “A Concise Synthesis of Ximenynic Acid”, Synth. Commun. 2012, 42, 3540-3543.
4.Lei Yang, Xiaowen Xue*, Yihua Zhang, “Simple and Efficient Synthesis of Belinostat”, Synth. Commun. 2010, 40, 2520-2524.
5.Xueqing Zhao, Fei Li, Weiping Zhuang, Xiaowen Xue*，Yuanyang Lian, Jianhui Fan, Dongsheng Fang,“A New Method for Synthesis of Nolatrexed Dihydrochloride”, Org. Process Res. Dev. 2010, 14, 346-350.
6.Xueqing Zhao*, Weiping Zhuang, Dongsheng Fang, Xiaowen Xue*, Jingming Zhou, “A Highly Efficient Conversion of Primary or Secondary Alcohols into Fluorides with n-Perfluorobutanesulfonyl Fluoride-Tetrabutylammonium Triphenyldifluorosilicate”, Synlett 2009, 779-782.
7.Benjamin W. Gung*, Xiaowen Xue and Zou Yan, “Enthalpy (H) and Entropy (S) for π-Stacking Interactions in Near-Sandwich Configurations: Relative Importance of Electrostatic, Dispersive, and Charge-Transfer Effects”, J. Org. Chem. 2007, 72，2469-2475.
8.Benjamin W. Gung*, Xiaowen Xue and Hans J. Reich, “Off Center Oxygen-Arene Interactions in Solution: A Quantitative Study”, J. Org. Chem. 2005, 70, 7232-7237.
9.Benjamin W. Gung*, Xiaowen Xue and Hans J. Reich, “The Strength of Parallel- Displaced Arene-Arene Interactions in Chloroform”, J. Org. Chem. 2005, 70, 3641-3644.
10.Benjamin W. Gung,* Xiaowen Xue, and William R. Roush, “The origin of diastereofacial control in allyboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen”, J. Am. Chem. Soc. 2002, 124, 10692.

聯(lián)系方式：xwenxue@cpu.edu.cn