北京理工大學(xué)化學(xué)學(xué)院研究生導(dǎo)師介紹：張小玲

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姓名：張小玲

性別：女

出生年月：1963.3

職務(wù)職稱：教授，博士生導(dǎo)師

聯(lián)系電話：68913154

傳真：010-88875298

電子郵件：zhangxl000@126.com；zhangxl@bit.edu.cn

主要經(jīng)歷：
分別于1984年、1987年陜西師范大學(xué)化學(xué)系獲理學(xué)學(xué)士、碩士學(xué)位，隨后留校任教。2003年獲西北大學(xué)分析化學(xué)專業(yè)博士學(xué)位，2005年調(diào)入北京理工大學(xué)理學(xué)院化學(xué)系任教授、博士生導(dǎo)師。期間2005年12月應(yīng)日本筑波產(chǎn)業(yè)技術(shù)綜合研究所（NationalInstitute of Advanced Industrial Science and Technology,AIST）邀請作為特聘研究員從事研究工作，2008-2009年美國佛羅里達(dá)大學(xué)（University of  Florida）訪問教授。主要從事新型光學(xué)探針試劑及功能化納米晶的設(shè)計(jì)合成及其在分子識(shí)別與化學(xué)生物傳感中的應(yīng)用研究。

研究方向：

1.新型光學(xué)探針分子的設(shè)計(jì)、合成

2.功能化納米晶及納米結(jié)構(gòu)的設(shè)計(jì)、合成、組裝

3.分子識(shí)別與化學(xué)生物傳感

研究內(nèi)容：
針對(duì)目前環(huán)境污染、食品安全、疾病的早期診斷及藥物靶向治療等人類所面對(duì)的問題中所必需的高靈敏度、高特異性化學(xué)生物識(shí)別傳感學(xué)方法和器件研究，利用光誘導(dǎo)電子轉(zhuǎn)移、電荷轉(zhuǎn)移、能量轉(zhuǎn)移等各種光物理過程，和酶、抗體、單鏈DNA和核酸識(shí)體、信號(hào)肽等生物分子識(shí)別物質(zhì)，設(shè)計(jì)合成性能優(yōu)異的光學(xué)(包括吸光、熒光、發(fā)光)探針分子或功能化納米晶，構(gòu)建組裝針對(duì)不同目標(biāo)物的分子和生物納米識(shí)別體系，實(shí)現(xiàn)對(duì)生命體系或環(huán)境體系中重要目標(biāo)物(包括陰陽離子，中性小分子，生物大分子，病毒，細(xì)菌，腫瘤細(xì)胞，病變組織等)的光電化學(xué)識(shí)別傳感，探索識(shí)別機(jī)制及其化學(xué)本質(zhì)，應(yīng)用于對(duì)生命、環(huán)境、食品等復(fù)雜體系中具有重要影響力目標(biāo)物的特異性標(biāo)記和遠(yuǎn)程、活體、原位、實(shí)時(shí)檢測或顯微成像分析等。

承擔(dān)課題：主持或參加國家自然科學(xué)基金及其他軍工項(xiàng)目多項(xiàng)：

1.國家自然科學(xué)基金資助項(xiàng)目“近紅外分子/納米熒光探針制備及其在腫瘤分子成像分析中的應(yīng)用研究”，主持人

2.信號(hào)肽介導(dǎo)亞細(xì)胞區(qū)域靶位近紅外Ca2+熒光納米傳感器的研究，國家自然科學(xué)基金項(xiàng)目

3.高選擇性硫醇探針的設(shè)計(jì)合成及分析應(yīng)用，北京分子科學(xué)國家實(shí)驗(yàn)室開放課題基金

4.推進(jìn)劑裝藥老化性能表征方法研究，橫向

5.火炸藥原材料數(shù)據(jù)庫，橫向

主要成果：已發(fā)表學(xué)術(shù)論文百余篇，申請國家發(fā)明專利6項(xiàng)，參編或主編出版教材4部，獲省科技進(jìn)步二等獎(jiǎng)兩項(xiàng)。

Selected Publications：

1.Xiaoman Zhai,  Wen Yang*,Mengyao Li,Guiqin Lv, Jinping Liu and Xiaoling Zhang*,Noncovalent hybrid of CoMn2O4 spinel nanocrystals and poly (diallyldimethylammonium chloride) functionalized

carbon nanotubes as efficient electrocatalysts for oxygen reduction reaction, Carbon, 2013, 65:277-286

2.Fang Zhang, Simiao Niu, Wenxi Guo, Guang Zhu, Ying Liu, Xiaoling Zhang, and Zhong Lin Wang, Piezo-phototronic Effect Enhanced Visible/UV Photodetector of a Carbon-Fiber/ZnO-CdS Double-

Shell Microwire, ACS NANO, 2013, 7(5): 4537-4544.

3.Fang Zhang, Yan Fang, Xiaoling Zhang*, Fluorescence Emission Properties of C60 Nanoparticles. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2013, 106:242-6.

4.Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia and Yamin Li, A Highly Selective Wavelength-Ratiometric And Colorimetric Probe For Cysteine, Dyes and Pigments., 2012, 94(1):10-

15. 

5.Xiaodan Zeng, Xiaoling Zhang *, WenYang *,Hongying Jia and Yamin Li, Fluorescence detection of adenosine triphosphate through an aptamer–molecular beacon multiple probe, Analytical

Biochemistry, 2012, 424(1): 8–11.

6.Xiaomiao Hou, Xiaoling Zhang *, Shutang Chen, Huaizhi Kang, Weihong Tan *,Facile synthesis of Ni/Au‚ Ni/Ag hybrid magnetic nanoparticles New active substrates for surface enhanced Raman

scattering, Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2012, 403: 148-154．

7.Liguo Wang, Qi Zhou, Baocun Zhu*, Liangguo Yan, Zhenmin Maa, Bin Du, Xiaoling Zhang*,A colorimetric and fluorescent chemodosimeter for discriminative and simultaneous quantification of

cysteine and homocysteine, Dyes and Pigments, 2012,95：275-279.

8.Xiaomiao Hou, Xiaoling Zhang *, Wen Yang*, Yu Liu, Xiaoman Zhai , Synthesis of SERS active Ag2S nanocrystals using oleylamine as solvent‚ reducing agent and stabilizer, Materials Research

Bulletin, 2012,47: 2579–2583.

9.Xiaoman Zhai , Xiaoling Zhang *, Shutang Chen,Wen Yang*,Zheng Gong,Oleylamine as solvent and stabilizer to synthesize shape-controlled ZnS nanocrystals with good optical properties, 

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2012,409:126-129

10.Fang Zhang, Yong Ding, Yan Zhang, Xiaoling Zhang, and Zhong Lin Wang, Piezo-phototronic Effect Enhanced Visible and Ultraviolet Photodetection Using a ZnO-CdS Core-Shell Micro/nanowire, ACS

NANO, 2012, 6(10): 9229-9236.

11.Huaizhi Kang, Haipeng Liu, Xiaoling Zhang*, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim and Weihong Tan*, Photoresponsive DNA-Crosslinked Hydrogels for Controllable Release and

Cancer Therapy, Langmuir, 2011, 27(1), 399-408. (This work has been highlighted by NATURE, 2011, 470: 9, 3 FEBRUARY, 2011)

12.Yamin Li , Xiaoling Zhang*, Baocun Zhu, Juan Xue, Zhi Zhu and Weihong Tan*,A simple but highly sensitive and selective colorimetric and fluorescent probe for Cu2+ ion aqueous media,

Analyst, 2011, 136, 1124-1128. (Was one of the top five most-read articles from the online version of Analyst for January 2011.)

13.Yamin Li , Xiaoling Zhang*, Baocun Zhu, Juan Xue, Jilin YAN, A Disulfide-linked Naphthalimide Dimer for Hg(II) Detection in Aqueous Solution, JOURNAL OF FLUORESCENCE,2011,21(4)：1343-1348

14.Shutang Chen, Xiaoling Zhang*, Qiuhua Zhang, Xiaomiao Hou, Qi Zhou , Jilin Yan ,Weihong Tan* . CdSe quantum dots decorated by mercaptosuccinic acid as fluorescence probe for Cu2+, Journal of
Luminescence, 2011, 131 , 947–951.

15.Xiaomiao Hou, Xiaoling Zhang*, Shutang Chen,Yan Fang, Jilin Yan, NaLi, Pengxu Qi. Facile synthesis of SERS active Ag nanoparticles in the presence of tri-n-octylphosphine sulfide, Applied
Surface Science, 2011, 257,  4935-4940

16.Na Li, Xiaoling Zhang*, Shutang Chen, Xiaomiao Hou, Yu Liu, Xiaoman Zhai.  Synthesis and Optical Properties of CdS nanorods and CdSe nanocrystals Using Oleylamine as both Solvent and
Stabilizer, Materials Science and Engineering B, 2011,176 (8): 688-691.

17.Xiaomiao Hou, Xiaoling Zhang*, Shutang Chen, Yan Fang, Na Li, Xiaoman Zhai, Yu Liu. Size-controlled synthesis of Au nanoparticles and nanowires and their application as SERS substrates.
Colloids and Surfaces A: Physicochem. Eng. Aspects, 2011, 384(1-3): 345-351.

18.Kang, Huaizhi; Trondoli, Anna; Zhu, Guizhi; Chen, Yan; Chang, Ya-Jen; Liu, Haipeng; Huang, Yu-Fen; Zhang, Xiaoling*; Tan, Weihong* . Near-Infrared Light-Responsive Core-Shell Nanogels for
Targeted Drug Delivery, ACS Nano, 2011, 5 (6): 5094–5099.

19.Na Li, Xiaoling Zhang*, Shutang Chen, Xiaomiao Hou. Synthesis and Characterization of CdS Nanoparticles in the Presence of Oleic Acid as Solvent and Stabilizer. Journal of Physics and
Chemistry of Solids,2011,72：1195-1198.

20.Baocun Zhu, Fang Yuan, Rongxia Li, Yamin Li, Qin Wei, Zhenmin Ma*, Bin Du,* and Xiaoling Zhang*,A highly selective colorimetric and ratiometric fluorescent chemodosimeter for imaging
fluoride ion in living cells,Chem. Commun., 2011, 47: 7098-7100.

21.Baocun Zhu, Chenchen Gao, Yunzhou Zhao, Caiyun Liu, Yamin Li, Qin Wei, Zhenmin Ma, Bin Du* and Xiaoling Zhang*,A 4-hydroxynaphthalimide-derived ratiometric fluorescent chemodosimeter for
imaging palladium in living cells,Chem. Commun., 2011,47, 8656–8658.

22.Na Li, Xiao Ling Zhang*, Shu Tang Chen, Wen Yang, Zhi Hui Kang, Wei Hong Tan. One-pot Self-Assembly of Flower-like Cu2S Structures with Near-Infrared Photoluminescent Properties.
CrystEngComm. 2011, 13 (21), 6549 - 6554

23.Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia, Wen Yang*, Yamin Li and Juan Xue, A colorimetric and ratiometric fluorescent probe for quantitative detection of GSH at
physiologically relevant levels,Sensors & Actuators: B. Chemical,2011,159(1): 142-147

24.Xiaodan Zeng, Xiaoling Zhang *, Baocun Zhu, Hongying Jia and Yamin Li, A colorimetric and ratiometric fluorescent probe for quantification of bovine serum albumin,Analyst , 2011, 136 (19),
4008 - 4012

25.Shutang Chen,Xiaoling Zhang* ,Xiaomiao Hou,Qi Zhou, Weihong Tan, Synthesis of CdS–Au2S–Au hybrid dendritic nanostructures,Materials Letters,2010, 64(1): 489-492

26.Zhang Fang, Zhang Xiaoling*, On the fluorescence of C60 at room temperature, SCIENCE CHINA(Physics, Mechanics & Astronomy), 2010,53(1): 95-99

27.Baocun Zhu, Xiaoling Zhang, Hongyin Jia, Yamin Li, Shutang Chen and Sichun Zhang ,The Determination Of Thiols Based Using A Probe That Utilizes Both An Absorption Red-Shift And Fluorescence
Enhancement, Dyes and Pigments, 2010,86：87-92.

28.Baocun Zhu, Xiaoling Zhang*, Hongyin Jia, Yamin Li, Haipeng Liu,Weihong Tan.   Title : A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection , Organic &
Biomolecular Chemistry, 2010, 8（7）,1650 - 1654.

29.Baocun Zhu, Hongyin Jia, Xiaoling Zhang*, Yan Chen, Haipeng Liu,Weihong Tan. Engineering a Subcellular Targetable, Red-Emitting and Ratiometric Fluorescent Probe for Ca2+ and Its Bioimaging
Applications, Anal Bioanal Chem, 2010, 397:1245–1250

30.Shutang Chen,Xiaoling Zhang* ,Xiaomiao Hou,Qi Zhou, Weihong Tan, One-pot synthesis of PbSe hollow single-crystalline nanoboxes based on gas bubble assisted Ostwald ripening ,Crystal Growth
& Design, 2010,10（3）, 1257–1262

31.Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Huaizhi Kang, Chaoyong James Yang,* and Weihong Tan*, An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual
Detection, Angew. Chem. Int. Ed. 2010, 49, 1052 –1056

32.Shutang Chen,Xiaoling Zhang* ,Yanbing Zhao, Qiuhua Zhang, Effects of Reaction Temperature on the Size and Optical Properties of CdSe Nanocrystals, Bulletin of Materials Science,2010, 33（5
）：1–6.

33.Shutang Chen,Xiaoling Zhang* ,Binkun Chen, Qiuhua Zhang, Weihong Tan*,  ,Synthesis, characterization and photoluminescence of CdS hyperbranched nanocrystals by a simple solution chemistry
methods,  Journal of Nanoscience and Nanotechnology,2010,10（9）：5857-5863.

34.Shutang Chen,Xiaoling Zhang* ,Qiuhua Zhang, Jilin Yan, Weihong Tan, Synthesis, Characterization and Optical Properties of CdS nanorods by a Simple Solution Chemistry Method , Materials
Science and Engineering B, 2010, 166, 158-162

35.陳書堂，張小玲*，侯曉淼，周琦，CdS納米棒的制備、表征及其形成機(jī)理，物理化學(xué)學(xué)報(bào)，2010，26 (02): 511-514

36.Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu and Weihong Tan*,Single-Walled Carbon Nanotube as an Effective  Quencher, Analytical and Bioanalytical Chemistry,2010,396:73–
83

37. Lili Chen, Weiwei Tan, Jingbo Zhang, Xiaowen Zhou, Xiaoling Zhang∗, Yuan Linb∗,Fabrication of high performance Pt counter electrodes on conductive plastic substrate for flexible dye-
sensitized solar cells, Electrochimica Acta, 2010, 55(11) : 3721–3726

38.Li Li Chen, Jia Liu, Jing Bo Zhang, Xiao Wen Zhou, Xiao Ling Zhang*,Yuan Lin*, Low temperature fabrication of flexible carbon counter electrode on ITO-PEN for dye-sensitized solar cells,
Chinese Chemical Letters, 2010, 21(9): 1137-1140.

39.Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, Qi Zhou, Surface-enhanced Raman scattering of C60 on co-modified substrate of Fe3O4 and Au nanoparticles, Chemical Physics, 2010, 372:

1-5.封面文章

40.Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, NaLi, Qi Zhou, 1-Hexadecylamine as both Reducing Agent and Stabilizer to Synthesize Au, Ag Nanoparticles and Their SERS Application,
Journal of Nanoparticle Research,2010, 13(5): 1929-1936

41.Xiaomiao Hou, Xiaoling Zhang*, Yan Fang, Shutang Chen, NaLi, Qi Zhou, Synthesis of SERS Active Au Nanowires in Different Noncoordinating Solvents,  Journal of Nanoparticle Research.
2010,13(6): 2625-2632

42.Baocun Zhu, Xiaoling Zhang*, Yamin Li, Pengfei Wang,* Hongyan Zhang, and Xiaoqing Zhuang, A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications, Chem.
Commun., 2010, 46, 5710 - 5712.

43.ZHENG HaiRong*, XU LiangMin1, ZHANG ZhengLong, DONG Jun, CHEN ShuTang & ZHANG XiaoLing*, Fluorescence enhancement of acridine orange in a water solution by Au nanoparticles. SCIENCE CHINA
Physics, Mechanics & Astronomy, 2010, 53(10): 1799–1804,

44.Yamin Li , Xiaoling Zhang*, Baocun Zhu, Jilin YAN, and Weiping XU, A Highly Selective Colorimetric and “off-on-off” Fluorescent Probe for Fluoride Ion, Analytical Sciences, 2010, 26,
1077-1080.

45.Fang Zhang and Xiaoling Zhang*, Solvent-induced Optical Properties of C60, Journal of Luminescence, 2010, 130, 787-791.

46.Huaizhi Kang, Haipeng Liu, Xiaoling Zhang*, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim and Weihong Tan*, Photoresponsive DNA-Crosslinked Hydrogels for Controllable Release and
Cancer Therapy, Langmuir, 2010, 27, 399-408. (This work has been highlighted by NATURE, 2011, 470: 9, 3 FEBRUARY, 2011)

47.Shutang Chen, Xiaoling Zhang*, Yanbing Zhao, Jilin Yan and Weihong Tan. Preparation and Characterization of CdSe Nanoparticles in the Presence of Triocytlphosphine as Solvent and Capping
Agent.  Materials Letters,2009, 63(8): 712-714

48.Liu, Weimin; Xu, Liwei; Zhang, Hongyan; You, Juanjuan; Zhang, Xiaoling*; Sheng, Ruilong; Li, Huaping; Wu, Shikang; Wang, Pengfei.   Dithiolane linked thiorhodamine dimer for Hg2+
recognition in living cells. Organic & Biomolecular Chemistry, 2009, 7(4), 660-664.

49.Yu-Fen Huang, Dihua Shangguan, Haipeng Liu, Joseph A. Phillips, Xiaoling Zhang,Yan Chen, and Weihong Tan. Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor
cells. ChemBioChem, 2009, 10（5）, 862-868.

50.Shutang Chen, Xiaoling Zhang*, Qiuhua Zhang, Weihong Tan*,Trioctylphosphine as both solvent and stabilizer to synthesize CdS nanorods,Nanoscale Research Letters, 2009, 4:1159–1165

51.張芳，張小玲*，C60室溫?zé)晒獍l(fā)射現(xiàn)象研究，中國科學(xué)（G輯），2009，39（12）：1710-1715

52.Xianwu Zou, Tefu Qin, Luohua Huang, Xiaoling Zhang, Zhi Yang, and Yong Wang,Mechanisms and Main Regularities of Biomass Liquefaction with Alcoholic Solvents, Energy Fuels, 2009, 23, 5213–
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