華中農業大學

匡漢暉，男，1967年生于江西泰和。1988年獲江西農業大學學士學位；1991年獲北京林業大學碩士學位；1994-1998年在美國佐治亞大學(University of Georgia)學習，獲博士學位。博士畢業后于1998-2007年分別在以色列海法大學(University of Haifa)、美國加州大學戴維斯分校(University of California, Davis)和伯克萊分校(University of California, Berkeley)從事蔬菜抗病研究工作, 研究內容包括植物抗病基因的基因組學、群體遺傳學、分子進化、抗病基因克隆等。匡博士第一次詳細論述植物中的抗病基因不同的進化速度，為抗病基因的保存、利用以及快速克隆提供理論基礎。2008年受聘為長江學者特聘教授�，F為華中農業大學園藝林學學院蔬菜系教授，博士生導師。

聯系電話：027-87280752

Email: kuangfile@mail.hzau.edu.cn

研究方向：

課題組的研究領域是植物分子遺傳和基因組學。具體研究方向是植物抗病基因以及蔬菜特異性狀的遺傳和分子機理�，F有（2014）研究課題為：

1、抗病基因基因組學：植物中的抗病基因的全基因組分析，側重其分子進化

2、抗病基因的快速克隆。利用第二代測序技術與BSA相結合快速定位抗病基因。利用VIGS技術快速鑒定抗性候選基因

3、蔬菜花青素高含量的遺傳與分子機理。通過遺傳方法定位和克隆調控花青素含量的基因，并分析其作用機理。

4、變態膨大莖的遺傳和分子機理。萵筍、榨菜、苤藍等變態莖膨大的遺傳和分子機理。

5、生菜、甘藍結球性狀的遺傳和分子機理。

6、生菜不同葉型發育的分子機理

7、植物中微型轉座子的基因組學

學術論文：

1.Wei, C., Kuang, H., Li, F., Chen, J. (2014) The I2 resistance gene homologues in Solanum have complex evolutionary patterns and are targeted by miRNAs. BMC Genomics, 15(1):743

2.Zhang, Y., Yan, C., Kuang, H*. (2014) GC-content fluctuation around small RNA-generating sites. FEBS Letters 588:764-769

3.Chen, J., Hu, Q., Zhang, Y., Lu, C., Kuang, H. (2014) P-MITE: a database for plant miniature inverted-repeat transposable elements. Nucleic Acids Res 42(1):D1176-81

4.Lin, X., Zhang, Y., Kuang, H., Chen, J. (2013) Frequent loss of lineages and deficient duplications accounted for low copy number of disease resistance genes in Cucurbitaceae. BMC Genomics 14:335

5.Jia, J.,…Kuang H (27th author).,…Wang, J., (2013) Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation. Nature, 496:91-5

6.Guo, S.…Kuang, H (31st author),…Xu, Y. et al., (2012) The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet. 45(1):51-8.

7.Xu, Q.,…Kuang, H. (34th author),…Ruan, Y. (2012) The draft genome of sweet orange (Citrus sinensis). Nat Genet. 16;45(1):59-66.

8.Yin, L.F., Hu, M.J,, Wang, F., Kuang, H., Zhang, Y., Schnabel, G., Li, G.Q., Luo, C.X. (2012) Frequent gain and loss of introns in fungal cytochrome B genes. PLoS One. 7 (11)

9.Chen, J., Lu, C., Zhang, Y., Kuang H. (2012) Miniature inverted-repeat transposable elements (MITEs) in rice were originated and amplified predominantly after the divergence of Oryza and Brachypodium and contributed considerable diversity to the species. Mob Genet Elements. 2(3):127-132.

10.Luo, S., Zhang, Y., Hu, Q., Chen, J., Li, Q., Lu, C., Liu, H., Wang, W., Kuang, H. (2012) Dynamic nucleotide-binding-site and leucine-rich-repeat-encoding genes in the grass family. Plant Physiol, 159:197-210

11.Lu, C., Chen, J., Zhang, Y., Hu, Q., Su, W., Kuang，H. (2012) Miniature inverted-repeat transposable elements (MITEs) have been accumulated through amplification bursts and play important roles in gene expression and species diversity in Oryza sativa. Mol Bio Evol, 29:1005-1017

12.Li G., Huang S., Guo X., Li Y., Yang Y., Guo Z., Kuang H., Rietman H., Bergervoet M., Vleeshouwers V., van der Vossen EA., Qu D., Visser R., Jacobsen E., Vossen J. (2011) Cloning and characterization of R3b; Members of the R3 superfamily of late blight resistance genes show sequence and functional divergence. Mol Plant Microbe Interact, 24:1132-1142

13.Xu, X.,…Kuang, H. (31st author),…Visser, RG.（2011）Genome sequence and analysis of the tuber crop potato. Nature 475:189–195

14.Luo, S., Peng, J., Li, K., Wang, M., Kuang, H.（2011）Contrasting evolutionary patterns of the Rp1 resistance gene family in different species of Poaceae. Mol Bio Evol,　 28: 313-325　　　　　　　　　　　　　　　　　　　　　　

15.Kuang, H.,Padmanabhan, C., Li, F., Kamei,A., Bhaskar, P. B., Ouyang, S., Jiang, J., Buell, C. R., C. R., and Baker, B.(2009) Identification of miniature inverted-repeattransposable elements (MITEs) and biogenesisof their siRNAs in the Solanaceae: New functionalimplications forMITEs. Genome Res, 19: 42-56.

16.Kuang, H., J. van Eck，H., Sicard，D., Michelmore, R. and Nevo, E. (2008) Evolution and genetic population structure of prickly lettuce (Lactuca serriola) and its RGC2 resistance gene cluster. Genetics, 178: 1547-1558.

17.Kuang, H., Caldwell, K., Meyers, B. and Michelmore, R. (2008) Frequent sequence exchanges between Homologs of RPP8 inArabidopsis are not necessarily associated with genomic proximity. Plant J, 54: 69-80.

18.Zhang, L., Mojtahedi, H., Kuang, H., Baker, B. and Brown, C.R. (2007) The use of STS markers in the marker-assisted selection of Columbia root-knot nematode resistance introgressed from Solanum bulbocastanum. Crop Sci, 47: 2021-2026

19.Kuang, H., Ochoa, O., Nevo E., and Michelmore R. (2006) The resistance gene Dm3 is infrequent in natural populations of Lactuca serriola due to deletions and frequent gene conversions. Plant J, 47: 38-48

20.Kuang, H., F. Wei, M. Marano, U. Wirtz, X. Wang, J. Liu, W. Shum,J. Zaborsky, L. J. Tallon, W. Rensink, S. Lobst, P. Zhang, C. Tornqvist, A. Tek, J. Bamberg, J. Helgeson, W. Fry, F. You, M. Luo, J. Jiang, R. C. Buell and B. Baker. (2005)The R1 resistance cluster contains three groups of independently evolving, Type I R1 homologues and shows substantial structural variation among haplotypes of Solanum demissum. Plant J, 44: 37-51

21.Huang, S., van der Vossen, E.A.G, Kuang, H., Vleeshouwers, V.G.A.A., Zhang, N., Borm, T.J.A., van Eck, H.J., Baker,B., Jacobsen, E. and Visser,R.G.F. (2005)Comparative genomics enabled the isolation of the R3a late blight resistance gene in potato. Plant J, 42: 251-261

22.Kuang, H., Woo, S., Meyers, B., Nevo, E., Michelmore, R. (2004) Multiple genetic processes result in heterogeneous rates of evolution within the major cluster disease resistance genes in lettuce. Plant Cell, 16: 2870-2894.

23.Meyers, B., Kozik, A., Griego, A., Kuang, H., R.W. Michelmore (2003). Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis. Plant Cell 15: 809-834.

24.Song, J., Bradeen, J.M., Naess, S.K., Raasch, J.A.,Haberlach, G.T., Wielgus S.M.,Liu, J., Kuang, H., Austin-Phillips, S., Buell, C.B., Helgeson, J.P., and Jiang, J. (2003) Gene RB from Solanum bulbocastanum confers broad spectrum resistance against potato late blight pathogen Phytophthora infestans. Proc Natl Acad Sci USA 100: 9128-9133.