空軍軍醫大學

姓名：周四元

性別：男　

職稱：教授

學院：藥學系

研究方向：靶向遞藥系統與藥物代謝動力學研究

周四元，男， 2000年獲得第四軍醫大學藥理學專業博士學位, 2007-2009在美國康涅狄格州大學從事新藥篩選研究�，F任第四軍醫大學藥劑學教研室主任，教授，藥劑學專業碩士研究生導師，陜西省藥理學會常務理事，副秘書長，國家藥品價格評審專家。長期從事靶向遞藥系統與藥物代謝動力學研究，發表論文90余篇，其中SCI收錄論文18篇，獲得國家發明專利3項。2007年獲陜西省科技進步一等獎1項（第三）。在靶向遞藥系統研究方面，2005年獲國家科技部藥物制劑關鍵技術研究專項經費支持，針對抗腫瘤化療藥物在臨床應用過程中存在的問題，建立了大分子靶向藥物研究技術平臺，制備腫瘤靶向遞藥系統，通過藥效學及藥代動力學評價，可望篩選出腫瘤靶向性好、療效確切的遞藥系統。藥物代謝動力學研究2003年獲得國家科技部創新藥物臨床前藥物代謝動力學關鍵技術平臺建設專項經費支持，建立了肝微粒體、Caco-2細胞、HepG2細胞、原位小腸、肝臟灌流等藥物吸收代謝研究模型，以及生物介質中氨氯地平、白藜蘆醇苷等近30種藥物/代謝產物的HPLC以及LC/MS/MS檢測方法。藥物代謝動力學研究主要開展以下三個方面工作：（1）藥物吸收代謝篩選，（2）天然藥物代謝轉運機制研究，（3）新藥臨床前藥代動力學研究。

代表論文

1. Liu RW, Teng ZH, Yuan CJ, Huan ML, Liu XY, Zhou SY*. Liquid chromatography/positive-ion electrospray tandem mass spectrometry assay for nisoldipine in human plasma and its application to a pharmacokinetic study. Journal of Liquid Chromatography & Related Technologies.2011, 34(16): 1800-1810.

2. Zhang WD, Wang XJ, Zhou SY*, Gu Y, Wang R, Zhang TL, Gan HQ. Determination of free and glucuronidated kaempferol in rat plasma by LC-MS/MS: application to pharmacokinetic study.J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(23):2137-40.

3. Zhou SY, Mamdani M, Qanud K, Shen JB, Pappano AJ, Kumar ST, Jacobson KA, Hintze T, Recchia F, Liang B. Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac P2X purinergic receptors. J. Pharmacol. Exp. Ther. 2010,333(3):920-8.

4. Kumar TS, Zhou SY, Joshi BV, Balasubramanian R, Yang T, Liang BT, Jacobson KA. Structure-activity relationship of (N)-methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor. J.Med.Chem. 2010, 53(6):2562-76.

5. Zhang BL, He W, Shi X, Huan ML, Huang QJ, Zhou SY*. Synthesis and biological activity of the calcium modulator (R) and (S)-3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5- dicarboxylate. Bioorg. Med. Chem. Lett. 2010, 20(3):805-8.

6. Liu XY, Teng ZH, Zhang Y, Huan ML, Zhou SY. High performance liquid chromatography-tandem mass spectrometric determination of resveratrol and its metabolites in rat tissues. Analytical Letters. 2010,43(4): 557–569.

7. Zhou S, Yang R, Teng Z, Zhang B, Hu Y, Yang Z, Huan M, Zhang X, Mei Q. Dose-dependent absorption and metabolism of trans-polydatin in rats. J.Agric.Food Chem. 2009, 57(11):4572 -4579.

8. Huan ML, Zhou SY, Mei QB.Conjugation with α-linolenic acid improves cancer cell uptake and cytotoxicity of Doxorubicin. Bioorg.Med.Chem.Lett. 2009, 19(9): 2579-2584.

9.Zhou S, Zhang B, Liu X, Teng Z, Huan M, Yang T, Yang Z, Jia M, Mei Q. A new natural angelica polysaccharide based colon-specific drug delivery system. Journal of Pharmaceutical Science. 2009, 98(12):4756-68.

10.Zhou S, Hu Y, Zhang B, Teng Z, Gan H, Yang Z, Wang Q, Huan M, Mei Q. Dose-dependent absorption, metabolism, and excretion of genistein in rats. J.Agric.Food Chem. 2008, 56(18):8354-9.

11.Sonin D, Zhou SY, Cronin C, Sonina T, Wu J, Jacobson KA, Pappano AJ, Liang BT. Role of P2X purinergic receptors in the rescue of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008, 295(3):H1191-7.

12.Yang ZF, Zhou SY (co-first author), Yang TH, Liu XY, Mei QB. Pharmacokinetics of the analogs at C3 and C5 of m-nifedipine in beagle dogs. Biopharmaceutics and drug disposition. 2008, 29:485-494.

13.Teng ZH, Zhou SY (co-first author), Yang RT, Liu XY, Liu RW, Yang X, Zhang BL, Yang JY, Cao DY, Mei QB. Quantitation assay for absorption and first-pass metabolism of emodin in isolated rat small intestine using liquid chromatography-tandem mass spectrometry. Biol. Pharm. Bull. 2007, 30(9):1628-1633.

14.Teng ZH, Zhou SY, Ran YH, Liu XY, Liu RW, Yang X, Yuan CJ, Mei QB. Cellular absorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2 cells. Biosci. Biotechnol. Biochem. 2007, 71(7):1636-1643.