空軍軍醫大學

姓名：李小強

性別：男　

職稱：副教授

學院：藥學系

李小強，第四軍醫大學藥理學教研室副教授、副主任，碩士研究生導師，陜西省藥品保健食品審評專家。中國藥理學會、中國生物物理學會和美國生物物理學會會員。1999年畢業于西安交通大學藥學院，獲學士學位，畢業后參軍入伍至第四軍醫大學藥理學教研室工作。2007年6月獲第四軍醫大學醫學博士學位（學校首批碩-博連讀生）。2006年4月至2008年6月，赴美國Albany醫學院心血管科學研究中心進行博士研究生聯合培養和博士后研究工作。

目前負責國家自然科學基金課題2項、陜西省科技計劃項目1項、分題負責十一五國家“重大新藥創制”課題1項，2009年獲第四軍醫大學“青年英才支持計劃（第二層次）”研究基金資助；以主要完成人參與其他國家、軍隊、省部級課題10余項。

發表研究論文43篇，其中SCI收錄期刊20余篇；擔任Journal of Pharmacy and Pharmacology，International Immunopharmacology，《心臟雜志》和《細胞與分子免疫學雜志》等國內外期刊審稿人；申請國家發明專利2項。

任教以來，主講藥理學、臨床藥理學、臨床藥物治療學等課程，發表教學論文3篇，主編校內教材1部，參編專著4部，2011年獲第四軍醫大學“精品教員”稱號；曾多次獲嘉獎，榮立個人“三等功”1次。

研究方向：（1）離子通道在相關疾病中調控機制的基礎及應用研究；（2）活性天然產物的藥理作用及新藥研究。
 
發表的主要文章（*為通訊作者）：

1. Li XQ, Cao W, Zeng AG, Yang ZF, Xing B, Dong L, Zhang HF, Mei QB*. Different pharmacological properties of the optical isomers of MN9202, a novel 1,4-dihydropyridine Ca2+ channel modulator in rat ventricular myocytes. Clin Exp Pharmacol Physiol. 2010;37(8):817-825.

2. Li XQ, Zheng YM, Rathore R, Ma J, Takeshima H, Wang YX*. Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009;457(4): 771-783.

3. Li XQ*, Cao W, Li T, Zeng AG, Hao LL, Zhang XN, Mei QB. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol. 2009;9(9):1032-1041.

4. Li XQ, Zhao MG, Mei QB*, Zhang YF, Guo W, Wang HF, Chen D, Cui Y. Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. Acta Pharmacol Sin. 2003; 24(12): 1224-1230.

5. Li XQ, Zheng YM, Wang YX*. Functional importance of type-1 ryanodine receptor in smooth muscle cells. Biophysical Journal. 2008, 94(2) : 877-880.

6. Cao W, Li XQ*, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW*. Madecassoside suppresses LPS- induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. Int Immunopharmacol. 2010;10(7):723-729.

7. Cao W, Xie YH, Li XQ*, Zhang XK, Chen YT, Kang R, Chen X, Miao S, Wang SW*. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol. 2011 Jun 26.

8. Cao W, Li XQ(co-first), Wang X, Li T, Chen X, Liu SB, Mei QB*. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2010;46(1):115-122.

9. Cao W, Li XQ(co-first), Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB*. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010;17(8-9):598-605.

10. Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv ZG, Mei QB*. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydr Polymers. 2006;66(2):149-159.

11. Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, Mei Q*. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydr Res. 2006; 341 (11):1870-1877.

12. Rathore R, Zheng YM, Li XQ, Wang QS, Liu QH, Ginnan R, Singer HA, Ho YS, Wang YX*. Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in[Ca2+]i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 2006;351(3):784-790.

13. Liu QH, Zheng YM, Li XQ, Ma JJ, Takeshima H, Wang YX*. PKC epsilon Regulates Calcium Sparks By Selectively Interacting With Type-1 Ryanodine Receptors In Smooth Muscle Cells. Biophysical Journal. 2008, 94(2) : 150-157.

14. Liu QH, Zheng YM, Korde AS, Li XQ, Ma J, Takeshima H, Wang YX*. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol. 2009; 40(6):663-671.

15. Zhao MG, Mei QB, Zhang YF, Xing B, Li XQ, Cui Y. Inhibitory effects of serotonin on transient outward potassium current in rat ventricular myocytes. Acta Pharmacol Sin. 2002;23(7):617-622.