北京市結核病胸部腫瘤研究所

內科學

王敬慧，女，北京胸科醫院腫瘤二科主任醫師，醫學博士，副教授，碩士研究

生導師，腫瘤研究中心副主任。

長期從事肺癌等胸部腫瘤的臨床、科研和教學工作，對胸部腫瘤的診治具有豐富的臨床經驗。主要研究方向為肺癌免疫及肺癌個體化治療。共計發表論文80余篇，以第一或通訊作者在NatCommu、LungCancer等中外雜志上發表論文30余篇，并在ASCO、WCLC等會議上做壁報交流及口頭發言。曾獲北京市衛生局十百千“百”層次人才資助。獲批第三屆通州兩高人才。指導或協助培養碩士及博士研究生10余名。

代表作：

1.Nong J, Gong Y, Guan Y, Yi X, Yi Y, Chang L, Yang L, Lv J, Guo Z, Jia H, Chu Y, Liu T, Chen M, Byers L, Roarty E, Lam VK, Papadimitrakopoulou VA, Wistuba I, Heymach JV, Glisson B, Liao Z, Lee JJ, Futreal PA, Zhang S, Xia X, Zhang J, Wang J. Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun. 2018 Aug 6;9(1):3114. doi: 10.1038/s41467-018-05327-w. Erratum in: Nat Commun. 2019 Jan 29;10(1):552. PMID: 30082701; PMCID: PMC6079068.

2.Ma L, Li H, Wang D, Hu Y, Yu M, Zhang Q, Qin N, Zhang X, Li X, Zhang H, Wu Y, Lv J, Yang X, Yu R, Zhang S, Wang J. Dynamic cfDNA Analysis by NGS in EGFR T790M-Positive Advanced NSCLC Patients Failed to the First-Generation EGFR-TKIs. Front Oncol. 2021 Mar 25;11:643199. doi: 10.3389/fonc.2021.643199. PMID: 33842353; PMCID: PMC8030263.

3.Song H, Liu B, Dong B, Xu J, Zhou H, Na S, Liu Y, Pan Y, Chen F, Li L, Wang J. Exosome-Based Delivery of Natural Products in Cancer Therapy. Front Cell Dev Biol. 2021 Mar 2;9:650426. doi: 10.3389/fcell.2021.650426. PMID: 33738290; PMCID: PMC7960777.

4.Liu B, Wang Z, Gu M, Zhao C, Ma T, Wang J. GEO Data Mining Identifies OLR1 as a Potential Biomarker in NSCLC Immunotherapy. Front Oncol. 2021 Apr 20;11:629333. doi: 10.3389/fonc.2021.629333. PMID: 33959497; PMCID: PMC8095246.

5.Zhang X, Lv J, Wu Y, Qin N, Ma L, Li X, Nong J, Zhang H, Zhang Q, Yang X, Shi H, Wang J, Zhang S. HER2 Exon 20 Insertion Mutations in Lung Adenocarcinoma: Case Series and Response to Pyrotinib. Front Oncol. 2020 Jul 31;10:1162. doi: 10.3389/fonc.2020.01162. PMID: 32850330; PMCID: PMC7411254.