北京大學

李 馨 儒  博士，副教授，碩士研究生導師

電話: (10)-82801508

郵箱: ll@bjmu.edu.cn
 
1995年在沈陽藥科大學藥學系獲得藥物制劑專業學士學位。1998年在沈陽藥科大學獲得藥劑學理學碩士學位。2011年在北京大學藥學院獲得藥劑學在職博士學位。同年8月到北京醫科大學藥學院工作。主講物理化學、物理藥劑學實驗和藥用高分子材料學。參加的基金項目包括國家自然科學基金、973重大研究計劃、國家重大新藥創制專項新劑型與新釋藥系統技術平臺等。在國內、外學術期刊上發表論文20余篇。參編教材或專著2部。申請國家發明專利10項。主持完成了數個藥物制劑的研究開發工作。
 
研究方向    藥用高分子材料學  物理藥劑學

研究興趣

1. 多功能聚合物材料（合成、性質、評價及其應用）

2. 新型靶向給藥系統（腫瘤靶向、腦靶向等）

3. 納米制劑（脂質體、膠束、微乳等）
 
代表性論文
1. Xinru Li, Yanqing Huang, Xingwei Chen, Yanxia Zhou, Yan Liu, et al. Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin. Journal of Drug Targeting, 2009, 17(10):739-750.

2. Xinru Li, Yuanting Yue, Yanxia Zhou, Yan Liu, et al. An oil-free microemulsion for intravenous delivery of diallyl trisulfide: Formulation and evaluation. International Journal of Pharmaceutics, 2011, 407:158-166.     

3. Xinru Li, Yanhui Zhang, Yating Fan, Yan Liu, et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol. Nanoscale Research Letters, 2011, 6:275. 

4. Xinru Li, Pingzhu Li, Yan Liu, et al. Novel mixed polymeric micelles for enhancing delivery of anticancer drug and overcoming multidrug resistance in tumor cell lines simultaneously. Pharmaceutical Research, 2010, 27(8):1498-1511.  

5. Xinru Li, Xiaoyan Li, Yanxia Zhou, Yan Liu, et al. Development of patch and spray formulations for enhancing topical delivery of  sinomenine hydrochloride. Journal of Pharmaceutical Sciences, 2010, 99(4):1790-1799.

6. Xinru Li, Quan Yuan, Yanqing Huang, Yanxia Zhou, and Yan Liu. Development of silymarin self-microemulsifying drug delivery system with enhanced oral bioavailability. AAPS PharmSciTech, 2010, 11(2):672-678.

7. Xinru Li, Zhuoli Yang, Kewei Yang, Yan Liu, et al. Self-assembled polymeric micellar nanoparticles as nanocarriers for poorly soluble anticancer drug ethaselen. Nanoscale Resrarch Letters, 2009, 4:1502-1511.

8. Wang Fei, Xinru Li, Zhou Yanxia, Yan Liu, et al. Novel nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Molecular Pharmaceutics, 2010, 7(3):718-726.

9. Yanhui Zhang, Xinru Li, Yanxia Zhou, Yan Liu, et al. Cyclosporine A-loaded poly(ethylene glycol)-b-poly(D,L-lactic acid)  micelles: preparation, in vitro and in vivo characterization and transport mechanism across the intestinal barrier. Molecular Pharmaceutics, 2010, 7(4):1169-1182.

10. Ming Chen , Xinru Li, Yan-Xia Zhou, Yan Liu, et al. Improved absorption of salmon calcitonin by ultraflexible liposomes  through intranasal delivery. Peptides, 2009,30:1288-1295.