中國海洋大學(xué)

中國海洋大學(xué)海洋生命學(xué)院海洋生物系研究生導(dǎo)師董波介紹如下：

董波，博士，教授，博士生導(dǎo)師

E-mail: bodong@ouc.edu.cn

電話: 0532-82032733, 82032735 (o); 0532-82032732 (Lab.)

地址：青島市魚山路5號， 郵編266003

教育及工作背景：2005年獲中科院海洋所博士學(xué)位；2006-2010年在挪威卑爾根大學(xué)薩斯國際海洋分子生物學(xué)中心從事博士后工作；2010-2013年任日本理化學(xué)研究所神戶發(fā)育生物學(xué)中心國際特別研究員；2014年受聘擔(dān)任理化學(xué)研究所神戶發(fā)育生物學(xué)中心研究員；2014-2019年受聘擔(dān)任中國海洋大學(xué)筑峰工程特聘教授；2015-2019年受聘任山東省泰山學(xué)者海外特聘專家。

主要研究方向及成果：實(shí)驗(yàn)室的研究方向是動物組織器官發(fā)育的分子機(jī)制及細(xì)胞生物力學(xué)基礎(chǔ)。以果蠅和海鞘等模式動物為材料，通過細(xì)胞遺傳發(fā)育生物學(xué)技術(shù)手段，結(jié)合數(shù)學(xué)物理模型，研究囊泡極性運(yùn)輸、細(xì)胞骨架動態(tài)、胞外基質(zhì)物理特性及其對細(xì)胞行為的影響等。發(fā)現(xiàn)了脊索管腔形成的細(xì)胞學(xué)過程，揭示了調(diào)控細(xì)胞及器官形態(tài)發(fā)育變化的重要信號通路，建立了決定生物管腔幾何形狀的數(shù)學(xué)物理模型。研究結(jié)果相繼發(fā)表在PNAS, eLife, Nature Communications, Cell Reports, PLOS Biology, Development等國際主流雜志。

實(shí)驗(yàn)室目前有碩士、博士及博士后位置開放，并歡迎客座研究科學(xué)家交流合作。如果您對實(shí)驗(yàn)室研究領(lǐng)域和方向感興趣，并具有發(fā)育生物學(xué)、細(xì)胞生物學(xué)或生物物理學(xué)等背景，歡迎來信詢問。

Prof. Dr. Bo DONG:

2014.9-: Professor, Ocean University of China, Qingdao, China;

2013.11- 2014. 9: Research Scientist, RIKEN Center for Developmental Biology (CDB), Kobe, Japan.

2010.11- 2013.10: Foreign Postdoctoral Researcher, RIKEN CDB;

2006.10 - 2010.10: Postdoctoral fellow, Sars International Centre for Marine Molecular Biology, Bergen, Norway;

2001.7 - 2005.7: Ph.D., Institute of Oceanology, Chinese Academy of Sciences (IOCAS), Qingdao, China.

Research Interests

Our group is principally interested in uncovering cellular processes and the underlying mechanisms that support the biological tube formation. We use marine animal (Ciona) notochord and Drosophila tracheal system as models to understand the morphogenetic signaling network on polarized vesicle trafficking, cytoskeletal organization, membrane biogenesis and extracellular matrix dynamics during lumen formation and cell shape change.

Job and Contact

We are always looking for people with experience and interests in developmental biology, Cell biology or biophysics to join us. If you are interested in working with us as a graduate student, postdoc or visiting scientist, please contacts us for possible openings.

Laboratory for Molecular Mechanisms and Cellular Biophysics of Organogenesis

College of Marine Life Sciences, Ocean University of China

No.5 Yushan Road, 266003, Qingdao, China

Tel: 0532-82032733, 82032735 (o); 0532-82032732 (Lab.)

Email: bodong@ouc.edu.cn

Selected publications

1. Sehring I, Recho P, Denker E, Kourakis M, Mathiesen B, Hannezo E*, Dong B*, Jiang D*. Assembly and positioning of actomyosin rings by contractility and planar cell polarity. eLife, 2015. 4: e09206. (*Corresponding authors).

2. Hannezo E‡, *, Dong B‡, *, Recho P, Joanny JF, Hayashi S. A cortical instability drives periodic supracellular actin pattern formation in epithelial tubes. PNAS, 2015. 112 (28): 8620-8625. (‡Co-first authors; *Corresponding authors).

       Commentary in: Nir S. Gov, Saoirse S. McSharry, and Greg J. Beitel, Three-ring circus without a ringmaster: Self-organization of supracellular actin ring patterns during epithelial morphogenesis.PNAS, 2015 112 (28): 8521-8522.

3.董波。海洋模式動物海鞘及其脊索發(fā)育與調(diào)控。科學(xué)通報(bào)，2015，60: 1167-1179.

4. Denker E, Sehring I, Dong B, Audisso J, Mathiesen B, Jiang D. Regulation by a TGFβ-ROCK-actomyosin axis secures a non-linear lumen expansion that is essential for tubulogenesis.Development, 2015, 142: 1639-1650.

5. Dong B, Hayashi S. Shaping of biological tubes by mechanical interaction of cell and extracellular matrix. Current Opinion in Genetics & Development, 2015, 32: 129-134.

6. Dong B, Miao GX, Hayashi S. A fat body-derived apical extracellular matrix enzyme is transported to the tracheal lumen and is required for tube morphogenesis in Drosophila. Development, 2014, 141(21): 4104-4109.

Selected as a highlight in this issue “Fat body shapes up the trachea”, 

http://dev.biologists.org/content/141/21/e2102?etoc

7. Dong B*, Hannezo E, Hayashi S*. Balance between apical membrane growth and luminal matrix resistance determines the shape of epithelial tubule. Cell Reports,2014, 7(4): 941-950. (*Corresponding authors).

8. Sehring I‡, Dong B‡, Denker E, Deng W, Jiang D. An Equatorial Contractile Mechanism Drives Cell Elongation but not Cell Division. PLOS Biology, 2014, 12(2): e1001781. (‡Co-first authors)

Comment in: A real stretch: mechanisms behind cell elongation. [PLoS Biol. 2014]http://www.ncbi.nlm.nih.gov/pubmed/24503562

9. DongB, KakiharaK, Otani T, WadaH, Hayashi S. Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control. Nature Communications.2013, 4, 1358.

10. Dong B, Deng W, Jiang D, Distinct cytoskeleton populations and extensive crosstalk controlCiona notochord tubulogenesis. Development, 2011, 138 (8): 1631-1641.

Selected as a Recommended Read by Faculty of 1000. http://f1000.com/9601956

11. Dong B, Horie T, Denker E, Kusakabe T, Tsuda M, Smith WC, Jiang D. Tube formation by complex cellular processes in Ciona intestinalis notochord. Developmental Biology 2009, 330: 237-249.