華中農業大學

華中農業大學信息學院生物信息系研究生導師龔靜介紹如下：

龔靜，女，博士，教授，華中農業大學，信息學院，研究員，博士生導師

郵箱：gong.jing@mail.hzau.edu.cn

工作單位

華中農業大學信息學院

研究方向

遺傳變異的功能預測和實驗驗證。系統分析了人類中遺傳變異對miRNA、lncRNA、甲基化、基因表達、可變剪切等功能的影響。構建了一系列遺傳變異相關的數據庫（miRNASNP、lncRNASNP、PancanQTL、Pancan-meQTL、SplicingQTL）。并結合分子流行病學、分子生物學等技術鑒定及驗證了多個癌癥相關的易感位點及基因。

生物大數據的整合分析及挖掘。高通量測序數據分析及TCGA、ENCODE、GTEx等大型數據庫資源的整合分析。

教育經歷

2003.09-2008.06 華中科技大學，預防醫學系，醫學學士

2008.09-2013.06 華中科技大學，生物信息學系，工學博士

主要職歷

2013.07-2015.06 華中科技大學，公共衛生學院，博士后

2015.07-2017.12 華中科技大學，公共衛生學院，講師

2018.01-2018.09 華中科技大學，公共衛生學院，副教授，碩士生導師

2016.04-2018.04 美國，德克薩斯大學休斯頓健康科學中心(UThealth)，訪問學者

2018.09-至今 華中農業大學，信息學院，研究員，博士生導師

科研成果

主要致力于生物大數據的整合分析和腫瘤相關的分子流行病學研究。主持國家自然科學青年基金、中國博士后基金等課題。以第一作者或通訊作者在Annals of oncology、Nucleic Acids Research（4篇）、Cell Reports、Carcinogenesis、European journal of cancer等雜志上發表SCI 文章20多篇，累計影響因子超過100分，其中2篇論文被評為ESI高被引論文，1篇引用次數達250次。

代表性論文：

1. Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X. and Han, L. (2018) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic Acids Res. (IF:10.2)

2. Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs6983267. Annals of oncology. 29(3), 632-639. (IF: 11.8)

3. Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981. (IF: 8.3, 2017.11.14 Volume 21, Issue 7, 封面文章)

4. Gong, J., Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research. 46, D971-D976. (IF:10.2)

5. Gong, J., Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:10.2)

6. Gong, J., Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2, 引用70次，ESI高被引論文)

7. Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6, 引用255次)

8. Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:6.0)

9. Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Gong, J*. (2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021. (IF:4.2)

10. Gong, J., Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1, ESI高被引論文)

11. Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. and Gong, J.* (2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194. (IF:4.3)

12. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R., Gong, J.* and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207. (IF:5.2)

13. Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. and Gong, J.* (2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e0138478. (IF:2.8)

14. Gong, J., Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029. (IF:3.3)

15. Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L., Gong, J.* and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480. (IF:4.3)

16. Gong, J., Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385. (IF:3.9)

17. Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306. (IF:3.7)

18. Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B., Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.

19. Liu, D.＃, Gong, J.#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)

20. 龔靜, 柳純潔, 繆小平, 郭安源. 人類長鏈非編碼RNA 相關SNP 鑒定與功能預測的研究進展[J].生物技術通報,2015,11:1-8.

歡迎對生物信息學感興趣的博士后、研究生和本科生加入我們的研究小組！