北京理工大學

個人概況

特別研究員招生專業

化學工程與技術（生物化工），制藥工程

漢族

山西忻州

聯系方式

辦公室：yang_yu@outlook.com

北京理工大學 化學與化工學院

教育經歷

2008/8 - 2014/1，伊利諾伊大學香檳分校，生物物理和計算生物學，博士，論文題目: 使用非天然氨基酸進行蛋白質工程研究，導師：陸藝

2004/9 - 2008/7，北京大學，生物科學，學士

工作經歷

2018/3 – 至今: 北京理工大學化學與化工學院，特別研究員 2016/10 - 2018/3，中國科學院，天津工業生物技術研究所，副研究員 2014/3 – 2016/9，中國科學院，天津工業生物技術研究所，助理研究員

主要科研項目

1.科技部國家重點研發計劃“蛋白質機器與生命過程調控”青年項目、2017/01-2021/12、 500 萬元、在研、課題骨干。

2.中國科協“青年人才托舉工程”，2016/01-2018/12。

3.國家自然科學基金青年基金，31500641、裂解性多糖單加氧酶的功能機理研究、2016/01-2018/12、 20 萬元、在研、主持。

代表性論文

(1)Honghui Chen#, Binbin Su, Tongtong Zhang, Aiping Huang, Haiping Liu*, Yang Yu*, and Jiangyun Wang*. RSC Advances 2017, 7: 56093-56098.

(2)Cheng Hu#, Yang Yu#, and Jiangyun Wang*. (2017) Improving artificial metalloenzymes' activity by optimizing electron transfer, Chem. Commun. 53, 4173-4186.

(3)Yang Yu#, Chang Cui#, Xiaohong Liu#, Igor D. Petrik, Jiangyun Wang*, and Yi Lu*, A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme, J. Am. Chem. Soc., 2015 137: 11570-11573.

(4)Yang Yu#, Qing Zhou#, Li Wang, Xiaohong Liu, Wei Zhang, Meirong Hu, Jianshu Dong, Jiasong Li, Xiaoxuan Lv, Hanlin Ouyang, Han Li, Feng Gao, Weimin Gong, Yi Lu*, and Jiangyun Wang*, Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid, Chemical Science, 2015 6: 3881-3885.

(5)Yang Yu#, Xiaoxuan Lv#, Jiasong Li, Qing Zhou, Chang Cui, Parisa Hosseinzadeh, Arnab Mukherjee, Mark J. Nilges, Jiangyun Wang*, and Yi Lu*, Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs, J. Am. Chem. Soc., 2015 137: 4594-4597.

(6)Xiaoxuan Lv#, Yang Yu#, Meng Zhou, Cheng Hu, Feng Gao, Jiasong Li, Xiaohong Liu, Kai Deng, Peng Zheng, Weimin Gong, Andong Xia*, and Jiangyun Wang*, Ultrafast Photoinduced Electron Transfer in Green Fluorescent Protein Bearing a Genetically Encoded Electron Acceptor, J. Am. Chem. Soc., 2015 137: 7270-7273.

(7)Yang Yu#, Arnab Mukherjee#, Mark J. Nilges, Parisa Hosseinzadeh, Kyle D. Miner, and Yi Lu*, Direct EPR Observation of a Tyrosyl Radical in a Functional Oxidase Model in Myoglobin during both H2O2 and O2 Reactions, J. Am. Chem. Soc., 2014 136: 1174-1177.

(8)Jing Liu#, Saumen Chakraborty#, Parisa Hosseinzadeh#, Yang Yu#, Shiliang Tian, Igor Petrik, Ambika Bhagi, and Yi Lu*, Metalloproteins Containing Cytochrome, Iron–Sulfur, or Copper Redox Centers, Chem. Rev., 2014 114: 4366-4469.

(9)Yanchao Pan, Jing-Hua Jin, Yang Yu*, and Jiangyun Wang*, Significant Enhancement of hPrx1 Chaperone Activity through Lysine Acetylation, ChemBioChem, 2014 15: 1773-1776.

(10)Xiaohong Liu#, Yang Yu#, Cheng Hu, Wei Zhang, Yi Lu*, and Jiangyun Wang*, Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase, Angew. Chem., Int. Ed., 2012 51: 4312-4316.