湖南師范大學

湖南師范大學生命科學學院動物學研究生導師何善平介紹如下：

姓         名：何善平

職稱職務：特聘教授、博士生導師、國家青年****入選者        

專    業：生理學

研究領域：動物分子營養與免疫

聯系電話：0731-88872199/18670326886

電子郵箱：hesp@hunnu.edu.cn

通訊地址：湖南省長沙市麓山路36號湖南師范大學生命科學學院3號樓A224，郵編 410081

個人簡介

北京大學理學博士，湖南師范大學“瀟湘學者”特聘教授、博士生導師，國家青年****和湖南省百人計劃（青年）入選者，第十二屆湖南省政協委員。2002年獲華中農業大學農學學士學位（動物醫學專業），2011年獲北京大學理學博士學位（生物技術專業）；2011年至2016年，在美國南加州大學Keck醫學院分子微生物學與免疫學系從事博士后研究，研究腫瘤病毒調控天然免疫的分子機制。2016年作為海外高層次人才引進，加入印遇龍院士主持的動物營養與人體健康實驗室，從事動物營養與免疫方面的研究。近年來，在Molecular Cell、PLoS Pathogens、Nucleic Acids Research等國際權威期刊發表高水平SCI論文10余篇，多次參加國際學術會議并做大會報告，參與翻譯出版權威教材1部，獲中國發明專利3項。目前主持國家青年****項目、湖南省百人計劃項目、湖南省科技創新平臺與人才計劃（人才類）、瀟湘學者特聘教授科研項目等4項人才計劃項目。承擔本科生《人體及動物生理實驗》教學工作，指導本科生的國家級大學生創新性實驗。 

研究興趣

(1) 營養物質調控腸道天然免疫的分子機制

(2) 氨基酸感知、抗病毒天然免疫的翻譯后修飾調控

代表性論文

(1) He S., Zhao J., Song S., He X., Minassian A., Zhou Y., Zhang J., Brulois K., Wang Y., Cabo J., Zandi E., Liang C., Jung J., Zhang X., Feng P. (2015) Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Molecular Cell 58, 134-146. (IF, 14.018) (在當期Molecular Cell作為研究亮點獲得專評；Science Daily報道)

(2) Zhang J., He S., Wang Y., Brulois K., Lan K., Jung J., Feng P. (2015) Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase. PLoS Pathogens 11(3): e1004768. doi: 10.1371/journal.ppat.1004768. (IF, 8.057)

(3) Minassian A.#, Zhang J.#, He S., Zhao J., Zandi E., Saito T., Liang C., Feng P. An internally translated MAVS variant exposes its amino-terminal TRAF-binding motifs to deregulate interferon induction. PLoS Pathogens 11(7): e1005060. doi: 10.1371/journal.ppat.1005060. (#co-first author) (IF, 8.057)

(4) Zhao J., He S., Minassian A., Li J., Feng P. Recent advances on viral manipulation of NF-kappaB signaling pathway. Current Opinion in Virology 15, 103-111 (IF, 6.298)

(5) Zhang X., Wu Q., Cui S., Ren J., Qian W., Yang Y., He S., Chu J., Sun X., Yan C., Yu X., An C. (2015) Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. Journal of Experimental Botany 66, 2709-2721. (IF, 5.794)

(6) Zhang X., Wu Q., Ren J., Qian W., He S., Huang K., Yu X., Gao Y., Huang P., An C. (2012) Two Novel RING-type Ubiquitin Ligases, RGLG3 and RGLG4, Are Essential for Jasmonate-mediated Responses in Arabidopsis. Plant Physiology 160, 808-822. (IF, 7.394)

(7) He S., Tan G., Liu Q., Huang K., Ren J., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-Interacting Protein GILP Is a LITAF Domain Protein That Negatively Regulates Hypersensitive Cell Death in Arabidopsis. PLoS ONE 6(4): e18750. doi: 10.1371/journal.pone.0018750. (IF, 4.411)

(8) He S., Huang K., Zhang X., Yu X., Huang P., and An C. (2011) The LSD1-type Zinc Finger Motifs of Pisum sativa LSD1 Are a Novel Nuclear Localization Signal and Interact with Importin Alpha. PLoS ONE 6(7): e22131. doi: 10.1371/journal.pone.0022131. (IF, 4.411)

(9) Qian, W., Tan, G., He, S., Zhang, X., Zhang, X., Gao, Y., Liu, H., and An, C. (2007) Identification of a new AT-rich-element binding factor PsATF1 and its combined effect with PsGBF on the activation of PsCHS1 promoter. Frontiers in Bioscience 12, 1670-1679. (IF, 4.249)

(10) Qian, W., Tan, G., Liu, H., He, S., Gao, Y., and An, C. (2007) Identification of a bHLH-type G-box binding factor and its regulation activity with G-box and Box I elements of the PsCHS1 promoter. Plant Cell Reports 26, 85-93. (IF, 3.071)

(11) Tan, G., Gao, Y., Shi, M., Zhang, X., He, S., Chen, Z., and An, C. (2005) SiteFinding-PCR: a simple and efficient PCR method for chromosome walking. Nucleic Acids Research 33, e122. (IF, 9.112)