中國(guó)科學(xué)技術(shù)大學(xué)

張智軍
單位：中國(guó)科學(xué)院蘇州納米技術(shù)與納米仿生研究所
地址：江蘇省蘇州工業(yè)園區(qū)若水路398號(hào)
郵編：215123
電話：0512-62872556
個(gè)人主頁(yè)：http://biomed.sinano.ac.cn/ketizu/index.php?id=32

個(gè)人簡(jiǎn)歷  Personalresume 
張智軍，男，1963年生，中科院蘇州納米所研究員、博士生導(dǎo)師。1984年和1987年在中國(guó)西北大學(xué)分獲學(xué)士和碩士學(xué)位。1998年在日本關(guān)西學(xué)院大學(xué)獲理學(xué)博士。此后曾在北京大學(xué)、日本名古屋大學(xué)、加拿大國(guó)家研究院和McGill大學(xué)從事納米材料的合成及應(yīng)用研究。2007年底回國(guó)加入蘇州納米所，從事新型納米載藥系統(tǒng)和納米診療一體化平臺(tái)的構(gòu)建以及納米支架材料用于調(diào)控干細(xì)胞功能的研究。迄今為止在包括NatureMaterials，NanoLetters，AdvancedMaterials及Biomaterials等國(guó)際學(xué)術(shù)刊物發(fā)表論文70余篇，獲美國(guó)專利1項(xiàng)、中國(guó)專利6項(xiàng)。2010年以來(lái)發(fā)表的40余篇論文中，8篇入選Top10mostread/cited、亮點(diǎn)或封面文章；共引用2300余次，其中單篇引用超600次的1篇，超100次的7篇。受邀在國(guó)際著名學(xué)術(shù)刊物撰寫綜述3篇、納米醫(yī)學(xué)專著章節(jié)2篇。獲2015年度教育部自然科學(xué)獎(jiǎng)二等獎(jiǎng)（排名第2）。已培養(yǎng)3名博士后，6名博士，5名碩士。課題組研究生曾獲中國(guó)科學(xué)院院長(zhǎng)優(yōu)秀獎(jiǎng)（2011）、中國(guó)科學(xué)院朱李月華優(yōu)秀博士生獎(jiǎng)（2015）、中國(guó)科學(xué)院南京分院伍宜孫獎(jiǎng)學(xué)金（2011,2013）、研究生國(guó)家獎(jiǎng)學(xué)金（2012）以及全國(guó)博士生學(xué)術(shù)年會(huì)優(yōu)秀論文獎(jiǎng)(2012)等。

主要論文
31.Ma,Y.F.;Huang,J.;Song,S.J.;Chen,H.B.*;Zhang,Z.J.*Cancer-TargetedNanotheranostics:RecentAdvancesandPerspectives(Review),Small,2016,DOI:10.1002/smll.201600635.
30.Ma,Y.F.;Wang,H.M.,Yan,D.;Wei,Y.Q.;Cao,Y.H.;Yi,P.W.;Zhang,H.L.;Deng,Z.W.;Dai,J.W.;Liu,X.T.;Luo,J.X.;Zhang,Z.J.;*Sun,S.Q.;*Guo,H.C.*MagneticResonanceImagingRevealedSplenicTargetingofCanineParvovirusCapsidProteinVP2,Sci.Rep.2016,6,23392;DOI:10.1038/srep23392.
29.Tu,X.L.;Wang,L.N.;Cao,Y.H.;Ma,Y.F.;Shen,H.;Zhang,M.X;Zhang,Z.J.*Efficientcancerablationbycombinedphotothermalandenhancedchemo-therapybasedoncarbonnanoparticles/doxorubicin@SiO2nanocomposites,Carbon,2016,97,35-44.
28.Shen,H.;Ma,Y.F.;Luo,Y.;Liu,X.Y.;Zhang,Z.J.*;Dai,J.W.*Directedosteogenicdifferentiationofmesenchymalstemcellinthree-dimensionalbiodegradablemethylcellulose-basedhydrogelscaffold,ColloidsandSurfacesB:Biointerfaces,2015,135,332-338.
27.Huang,J.;Guo,M.;Ke,H.T.;Zong,C.;Ren,B.*;Liu,G.;Shen,H.;Ma,Y.F.;Wang,X.Y.;Zhang,H.L.;Deng,Z.W.;Chen,H.B.*;Zhang,Z.J.*Rationaldesignandsynthesisofmagneticgoldnanoflowersforefficientcancertheranostics,Adv.Mater.2015,27,5049-5056.
26.Luo,Y.;Shen,H.;Fang,Y.X.;Cao,Y.H.;Huang,J.;Dai,J.W.*;Shi,X.Y.*;Zhang,Z.J.*Enhancedproliferationandosteogenicdifferentiationofmesenchymalstemcellsonelectrospungrapheneoxide-incorporatedpoly(lactic-co-glycolicacid)nanofibrousmats,ACSAppl.Mater.Interfaces,2015,7,6331–6339.
25.Zhang,M.X.;Cao,Y.H.;Wang,L.N.;Ma,Y.F.;Tu,X.L.;Zhang,Z.J*,ManganesedopedironoxidetheranosticnanoparticlesforcombinedT1magneticresonanceimagingandphotothermaltherapy,ACSAppl.Mater.Interfaces,2015,7,4650-4658.
24.Guo,M.;Huang,J.;Shen,H.:Ma,Y.F.;Zhang,M.X.;Zhu,A.;Li,Y.L.;He,H.;Wang,Y.Y.;Tian,X.;Ge,C.C.;Zhang,Z.J.;*Chen,H.B.*Near-infraredfluorescentcyanine-graftedgrapheneoxidewithenhancedintrinsicphotothermalperformanceforinvivotumoreradication,Adv.Funct.Mater.2015,25,59–67.
23.Cao,Y.H.;Ma,Y.F.;Wang,H.M.;Zhang,M.X.;Tu,X.L.;Shen,H.;Dai,J.W.;Guo,H.C.*;Zhang,Z.J.*Ultra-smallgrapheneoxide-supportedgoldnanoparticlesasadjuvantimproveshumoralandcellularimmunityinmouse,Adv.Funct.Mater.2014,24,6963–6971.
22.Ma,Y.F.;Shen,H,;Tu,X.L.;Zhang,Z.J.*Accessinginvivotoxicityofgraphenematerials:currentmethodsandfutureoutlook(Review),Nanomedicine,2014,9,1565-1580.
21.Chong,Y.;Ma,Y.F.;Shen,H.;Zhou,X.;Xu,J.Y.;Fan,S.J.*;Zhang,Z.J.*Invitroandinvivotoxicityofgraphenequantumdots,Biomaterials,2014,35,5041-5048.
20.Tu,X.L.;Ma,Y.F.;Cao,Y.H.;Zhang,M.X.;Zhang,Z.J.*PEGylatedcarbonnanoparticlesforefficientinvitrophotothermalcancertherapy,J.Mater.Chem.B,2014,2,2184-2192.
19.Zhang,M.X.;Cao,Y.H.;Chong,Y.;Ma,Y.F.;Zhang,H.L.;Deng,Z.W.;Hu,C.H.;Zhang,Z.J.*GrapheneOxideBasedTheranosticPlatformforT1-WeightedMagneticResonanceImagingandDrugDelivery,ACSAppl.Mater.Interfaces,2013,5,13325-13332.
18.Shen,H.;Liu,M.;Chong,Y.;Huang,J.;Zhang,Z.J.*Synthesis,proteindelivery,andinvitroandinvivotoxicityofabiodegradablepoly(aminoester),Toxicol.Res.2013,2,379-387.
17.Cao,Y.H.;Chong,Y.;Shen,H.;Zhang,M.X.;Zhu,Y.M.;Zhang,Z.J.*CombinationofTNF-αandGrapheneOxide-LoadedBEZ235toEnhanceApoptosisofPIK3CAMutantColorectalCancerCells,J.Mater.Chem.B,2013,1,5602-5610.
16.Huang,J.;Zong,C.;Shen,H.;Liu,X.J.;Ren,B.;*Zhang,Z.J.*IntracellularTrackingofDrugReleasefromGrapheneOxidebySurface-EnhancedRamanSpectroscopy,Nanoscale,2013,5,10591-10598.
15.Liu,G.;Shen,H.;Mao,J.N.;Zhang,L.M.;Jiang,Z.;Sun,T.;Lan,Q.;*Zhang,Z.J.*Transferrinmodifiedgrapheneoxideforglioma-targeteddrugdelivery:invitroandinvivoevaluations,ACSAppl.Mater.Interfaces,2013,5,6909-6914.
14.Zhang,L.M.;Wang,Z.L.;Lu,Z.X.;Shen,H.;Huang,J.;Zhao,Q.H.;Liu,M.;He,N.Y.;*Zhang,Z.J.*PEGylatedReducedGrapheneOxideasaSuperiorssRNADeliverySystem,J.Mater.Chem.B,2013,1,749-755.
13.Shen,H.;Liu,M.;He,H.X.;Zhang,L.M.;Huang,J.;Chong,Y.;Dai,J.W.;Zhang,Z.J.*PEGylatedGrapheneOxide-MediatedProteinDeliveryforCellFunctionRegulation,ACSAppl.Mater.Interfaces,2012,4,6317-6323.
12.Chen,W.H.;Cao,Y.H.;Liu,M.;Zhao,Q.H.;Huang,J.;Zhang,H.L.;Deng,Z.W.;Dai,J.W.;Williams,D.F.;Zhang,Z.J.*RotavirusCapsidSurfaceProteinVP4-CoatedFe3O4Nanoparticles:ATheranosticNanoplatformforEfficientCellularImagingandDrugDelivery,Biomaterials,2012,33,7895-7902.
11.Huang,J.;Zong,C.;Shen,H.;Liu,M.;Chen,B.;Ren,B.;Zhang,Z.J.*,MechanismofCellularUptakeofGrapheneOxideStudiedbySurface-EnhancedRamanSpectroscopy,Small,2012,8,2577-2584.
10.Shen,H.；ZhangL.M.;LiuM.;Zhang,Z.J.*BiomedicalApplicationsofGraphene(Review),Theranostics,2012,3,283-294.
9.Liu,M.;Chen,B.;Huang,J.;Zhang,L.M.;Zhang,Z.J.*Polyamidoamine-GraftedMultiwalledCarbonNanotubesforGeneDelivery:Synthesis,TransfectionandIntracellularTrafficking,BioconjugateChem.2011,22,2237-2243.
8.Chen,W.H.;Yi,P.W.;Zhang,Y.;Zhang,L.M.;Deng,Z.W.;Zhang,Z.J.*CompositesofAminodextran-CoatedFe3O4NanoparticlesandGrapheneOxideforCellularMagneticResonanceImaging,ACSAppl.Mater.Interfaces,2011,3,4085-4091.
7.Chen,B.;Liu,M.;Zhang,L.M.;Huang,J.;Yao,J.L.;*Zhang,Z.J.*Polyethylenimine-FunctionalizedGrapheneOxideasanEfficientGeneDeliveryVector,J.Mater.Chem.2011,21,7736-7741.
6.Zhao,Q.H.;Chen,W.H.;Chen,Y.D.;Zhang,L.M.;Zhang,J.P.;Zhang,Z.J.*Self-AssembledVirus-likeParticlesfromRotavirusStructuralProteinVP6forTargetedDrugDelivery,BioconjugateChem.2011,22,346-352.
5.Zhang,Y.;Chen,B.;Zhang,L.M.;Huang,J.;Chen,F.H.;Yang,Z.P.;Yao,J.L.;Zhang,Z.J.*ControlledassemblyofFe3O4magneticnanoparticlesongrapheneoxide,Nanoscale,2011,3,1446-1450.
4.Zhang,L.M.;Lu,Z.X.;Zhao,Q.H.;Huang,J.;Shen,H.;Zhang,Z.J.*EnhancedchemotherapyefficacybysequentialdeliveryofsiRNAandanticancerdrugsusingPEI–graftedgrapheneoxide,Small,2011,7,460-464.
3.Chen,F.H.;Zhang,L.M.;Chen,Q.T.;Zhang,Y.;Zhang,Z.J.*Synthesisofanovelmagneticdrugdeliverysystemcomposedofdoxorubicin-conjugatedFe3O4nanoparticlecoresandaPEG-functionalizedporoussilicashell,Chem.Commun.2010,46,8633-8635.
2.Huang,J.;Zhang,L.M.;Chen,B.;Ji,N.;Chen,F.H.;Zhang,Y.;Zhang,Z.J.*Nanocompositesofsize-controlledgoldnanoparticlesandgrapheneoxide:FormationandapplicationsinSERSandcatalysis,Nanoscale,2010,2,2733-2738.
1.Zhang,L.M.;Xia,J.G.;Zhao,Q.H.;Liu,L.W.;Zhang,Z.J.*Functionalgrapheneoxideasnanocarriersforcontrolledloadingandtargeteddeliveryofmixedanticancerdrugs,Small,2010,6,537-544.

研究方向  Researchdirection 
1、納米載藥體系與診療一體化納米平臺(tái)的構(gòu)建
2、納米支架材料對(duì)干細(xì)胞功能的調(diào)控
3、納米生物學(xué)效應(yīng)