中國藥科大學

孔毅,男，1968年4月出生，博士，中國藥科大學副教授，碩士研究生導師。

2001年獲中國藥科大學博士學位，2003年在南京大學與江蘇萬邦生化醫藥股份有限公司從事博士后研究工作。2010年5月-9月，英國帝國理工學院訪問學者；2012年10月-2013年11月，北卡羅萊納大學訪問學者。江蘇省青藍工程中青年學科帶頭人培養對象。

研究方向

1微生物藥物和生化與生物技術藥物的開發與應用
2天然生化活性物質及其功能基因的研究
探尋自然界中結構新穎、生理活性強的天然多肽，并研究其結構與功能的關系，為創新藥物研發服務。

主要研究技術包括:蛋白質及多肽的分離純化，多肽的結構分析，酶法及ELISA法活性篩選，體內外抗血栓活性及分子作用機制研究，計算機輔助藥物設計等。

發明專利：

申請發明專利10余件，其中授權專利5件。

科研項目：

主持國家自然科學基金1項,省級課題2項,美國強生制藥課題1項,企業課題6項.參與國家自然科學基金2項,重大新藥創制1項。

近五年發表論文(第一或通訊作者)

2015
Mei-Mei Chen, Xiao-Hui Ye, Xin Ming, Ya-Hui Chen, Ying Wang, Xing-Li Su, Wen Su and Yi Kong. A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates[J]. Scientific reports, 2015, 5.
Yi Kong, Ying Wang, Wei Yang, Zhou-Ling Xie, Zhi-Yu Li. LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa[J]. Journal of pharmacological sciences, 2015, 127(4): 462-466.
Xing-Li Su, Wen Su, Zhi-Long He, Xin Ming and Yi Kong. Tripeptide SQL Inhibits Platelet Aggregation and Thrombus Formation via Affecting PI3K/Akt Signaling[J]. Journal of cardiovascular pharmacology, 2015.
Xiao-Hui Ye, Mei-Mei Chen, Ya-Hui Chen, Xing-Li Su, Ying Wang, Wen Su, Yi Kong. Isolation and Characterization of a Novel Antithrombotic Peptide from Enzymatic Hydrolysate of Agkistrodon acutus Venom[J]. International Journal of Peptide Research and Therapeutics, 1-9.
Guangyan Cheng, Liying He, Zhibin Sun, Zhongli Cui, Yingxiang Du, Yi Kong. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. Journal of microbiology and biotechnology, 2015.
 
2014
Yi Kong, Cheng Xu, Zhi-Long He, Qiu-Mei Zhou, Jin-Bin Wang, Zhi-Yu Li, Xin Ming. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus[J]. Peptides, 2014, 53: 70-78.
Yi Kong, Shuai Li, Yu Shao, Zhi-Long He, Mei-Mei Chen, Xin Ming, Ji-Fu Wei. Antithrombotic Peptides from Scolopendra subspinipes mutilans Hydrolysates[J]. International Journal of Peptide Research and Therapeutics, 2014, 20(2): 245-252.
Yi Kong, Hao Chen, Yong-Qing Wang, Ling Meng and Ji-Fu Wei. Direct thrombin inhibitors: Patents 2002-2012 (Review)[J]. Molecular medicine reports, 2014, 9(5): 1506-1514.
Hao Chen, Min Jin, Yi-Fen Wang, Yong-Qing Wang, Ling Meng, Rong Li, Jia-Ping Wang, Li Gao, Yi Kong and Ji-Fu Wei. Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System[J]. BioMed research international, 2014
 
2013
Yi Kong, Yu Shao, Hao Chen, Xin Ming, Jin-Bin Wang, Zhi-Yu Li, Ji-Fu Wei. A novel factor Xa-inhibiting peptide from centipedes venom[J]. International journal of peptide research and therapeutics, 2013, 19(4): 303-311.
Yi Kong, Jing Hui, Yu Shao, Shi-Long Huang, Hao Chen and Ji-Fu Wei. Cytotoxic and anticoagulant peptide from Scolopendra subspinipes mutilans venom[J]. African J Pharm Pharmacol, 2013, 7: 2238-2245.
Yi Kong, Shi-Long Huang, Yu Shao, Shuai Li, Ji-Fu Wei. Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans[J]. Journal of ethnopharmacology, 2013, 145(1): 182-186.
 
2012
Jing Xiong, Li Bai, Wei Fang, Jianyang Fu, Weirong Fang, Juan Cen, Yi Kong, Yunman Li. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation[J]. European Journal of Pharmaceutical Sciences, 2012, 45(5): 552-558.
 
2011
Hongwen Zhao, Yi Kong, Hanjin Wang, Tianhua Yan, Feifei Feng, Jianmin Bian, Yan Yang and Haining Yu. A defensin‐like antimicrobial peptide from the venoms of spider, Ornithoctonus hainana[J]. Journal of Peptide Science, 2011, 17(7): 540-544.

聯系方式:

電話:025-83271282;e-mail:yikong668@163.com