中國藥科大學

王小兵，男，博士，副教授，碩士研究生導師，研究領域為天然活性成分研究與開發(fā)。

2001年畢業(yè)于漢中師范學院，獲化學教育專業(yè)學士學位；2005年畢業(yè)于陜西師范大學，獲有機化學專業(yè)碩士學位；2008年畢業(yè)于中國藥科大學，獲藥物化學專業(yè)博士學位。2008年7月留校天然藥物化學教研室工作，2011年6月晉升為副教授。2015年作為訪問學者，在The Scripps Research Institute的Jin-Quan Yu教授課題組從事有機合成中的碳氫活化和天然產物合成研究工作。現(xiàn)主持國家自然科學基金面上項目和江蘇省自然科學基金青年項目各一項，參與多項國家和省部級基金項目。

研究方向：

1.基于天然產物的合理藥物設計與研究；
2.天然產物結構修飾與全合成；
3.天然產物生物轉化研究。

主持的基金項目：

1.國家自然科學基金面上項目，基于天然產物“優(yōu)勢結構”和藥物“活性片段”具有均衡活性的多靶點阿爾茨海默病藥物分子研究，編號：81573313,2016~2019.
2.江蘇省自然科學基金青年項目，若干常見中草藥活性成分的酶促生物轉化研究，編號：BK20130664,2013~2016.

近三年主要論文：

1.Sai-Sai Xie, Xiaobing Wang, Neng Jiang, Wenying Yu, Kelvin D. G. Wang, Jin-Shuai Lan, Zhong-Rui Li, Ling-Yi Kong*. Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease. European Journal of Medicinal Chemistry, 2015, 95, 153-165.
 2.Neng Jiang, Xiao-Bing Wang, Zhong-Rui Li, Su-Yi Li, Sai-Sai Xie, Ming Huang, Ling-Yi Kong*. Design of a structural framework with potential use to develop balanced multifunctional agents against Alzheimer's disease. RSC Advances, 2015, 5, 14242-14255.
3.Jin-Shuai Lan, Sai-Sai Xie, Ming Huang, Ya-Jian Hu, Ling-Yi Kong*, Xiao-Bing Wang*. Chromanones: selective and reversible monoamine oxidase B inhibitors with nanomolar potency. Medchemcomm, 2015, 6, 1293-1302.
4.Weisi Xiong, Xiaobing Wang, Lingyi Kong*. Design and application of a biphasic system that enhances productivity of Daucus carota-catalyzed asymmetric reduction. Biotechnology Letters, 2015, 37, 1703-1709.
5.Ming Huang, Sai-Sai Xie, Neng Jiang, Jin-Shuai Lan, Ling-Yi Kong, Xiao-Bing Wang*. Multifunctional coumarin derivatives: Monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 508-513.
6.Sai-Sai Xie1, Jin-Shuai Lan1, Xiao-Bing Wang, Neng Jiang, Ge Dong, Zhong-Rui Li, Kelvin D. G. Wang, Ping-Ping Guo, Ling-Yi Kong*. Multifunctional tacrine–trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties. European Journal of Medicinal Chemistry, 2015, 93, 42-50.
7.Zhi-Min Wang, Sai-Sai Xie, Xue-Mei Li, Jia-Jia Wu, Xiao-Bing Wang*, Ling-Yi Kong*. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease. RSC Advances, 2015, 5, 70395-70409.
8.Xiao-Bing Wang1, Chang-Shui Yang1, Chao Zhang, Jun Luo, Ming-Hua Yang, Jian-Guang Luo, Wen-Ying Yu, Ling-Yi Kong*. Ten new calyxins from Alpinia katsumadai: a systematically studies on the stereochemistry of calyxins. Tetrahedron, 2014, 70, 8714-8722.
9.Su-Yi Li, Xiao-Bing Wang, Neng Jiang, Ling-Yi Kong*. Synthesis of (E)-1,4-Enediones from α-halo ketones through a sodium sulfinate mediated reaction. European Journal of Organic Chemistry. 2014, 8035-8039.
10.Li Su-Yi, Jiang Neng, Xie Sai-Sai, Wang Kelvin D. G., Wang Xiao-Bing*, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease. Organic & Biomolecular Chemistry 2014, 12, 801-814.
11.He Ye, Wang Xiao-Bing, Fan Bo-Yi, Kong Ling-Yi. Honokiol trimers and dimers via biotransformation catalyzed by Momordica charantia peroxidase: Novel and potent alpha-glucosidase inhibitors. Bioorganic & Medicinal Chemistry 2014, 22, 762-771.
12.Li Su-Yi, Wang Xiao-Bing, Kong Ling-Yi. Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. European Journal of Medicinal Chemistry 2014, 71, 36-45.
13.Xu Zi-Chen, Wang Xiao-Bing, Yu Wen-Ying, Xie Sai-Sai, Li Su-Yi, Kong Ling-Yi. Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2014, 24, 2368-2373.
14.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Yang Lei, Kong Ling-Yi*. Design, synthesis and evaluation of novel tacrine coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 64, 540-553.
15.Xie Sai-Sai, Wang Xiao-Bing*, Li Jiang-Yan, Kong Ling-Yi*. Design, Synthesis and Biological Evaluation of Novel 7-Mercaptocoumarin Derivatives as alpha(1)-Adrenoceptor Antagonists. Chemical & Pharmaceutical Bulletin 2013, 61, 16-24.
16.Wang Xiao-Bing1, Zhang Yao1, Wang Jun-Song, Gu Yu-Cheng, Kong Ling-Yi. Novel ring A rearranged isomers with gamma-lactone from the fruits of Aphanamixis grandifolia. Tetrahedron Letters 2013, 54, 6023-6028.
17.Li Su-Yi, Wang Xiao-Bing, Xie Sai-Sai, Jiang Neng, Wang Kelvin D. G., Yao He-Quan, Sun Hong-Bin, Kong Ling-Yi. Multifunctional tacrine flavonoid hybrids with cholinergic, beta-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 2013, 69, 632-646.
18.Li Ren-Shi, Wang Xiao-Bing, Hu Xiao-Jun, Kong Ling-Yi. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters 2013, 23, 2636-2641.
19.Hu Xiao-Jun, Wang Xiao-Bing, Kong Ling-Yi. alpha-Glucosidase Inhibitors via Green Pathway: Biotransformation for Bicoumarins Catalyzed by Momordica charantia Peroxidase. Journal of Agricultural and Food Chemistry 2013, 61, 1501-1508.
20.Bao Feng-Zu, Wang Xiao-Bing, Kong Ling-Yi. Pyrrolidine catalyzed novel domino reaction for the synthesis of polysubstituted 4-oxocyclohexanecarbaldehyde derivatives. Tetrahedron Letters 2013, 54, 1405-1408.

聯(lián)系方式：

通訊地址：南京市鼓樓區(qū)童家巷24號
郵政編碼：210009
電子信箱：xbwang@cpu.edu.cn
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